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Mechanochemical Preparation of Active Pharmaceutical Ingredients Monitored by In Situ Raman Spectroscopy

Sović, Irena; Lukin, Stipe; Meštrović, Ernest; Halasz, Ivan; Porcheddu, Andrea; Delogu, Francesco; Ricci, Pier Carlo; Caron, Fabien; Perilli, Thomas; Dogan, Anita; Colacino, Evelina (2020) Mechanochemical Preparation of Active Pharmaceutical Ingredients Monitored by In Situ Raman Spectroscopy. ACS Omega, 5 (44). pp. 28663-28672. ISSN 2470-1343

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Abstract

The mechanochemical preparation of silver sulfadiazine and dantrolene, two marketed active pharmaceutical ingredients, was investigated by in situ Raman spectroscopy. For the first time, the mechanochemical transformations involving highly fluorescent compounds could be studied in situ with a high- resolution Raman system combined with a unique suitable Raman probe. Moreover, the kinetic features of the mechanochemical process were examined by a mathematical model allowing to describe the chemical changes under mechanical stress. This approach is promising both to broaden the scope of Raman in situ investigations that would otherwise be impossible and for process optimization at any scale.

Item Type: Article
Uncontrolled Keywords: Ammonia ; Raman spectroscopy ; Chemical reactions ; Pharmaceuticals : Silver
Subjects: BIOMEDICINE AND HEALTHCARE > Pharmacy
Divisions: Division of Physical Chemistry
Depositing User: Stipe Lukin
Date Deposited: 25 Mar 2021 08:38
Last Modified: 25 Mar 2021 08:45
URI: http://fulir.irb.hr/id/eprint/6361
DOI: 10.1021/acsomega.0c03756

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