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Mechanobiology of the Mitotic Spindle

Pavin, Nenad; Tolić, Iva Marija (2021) Mechanobiology of the Mitotic Spindle. Developmental Cell, 56 (2). pp. 192-201. ISSN 15345807

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The mitotic spindle is a microtubule-based assembly that separates the chromosomes during cell division. As the spindle is basically a mechanical micro machine, the understanding of its functioning is constantly motivating the development of experimental approaches based on mechanical perturbations, which are complementary to and work together with the classical genetics and biochemistry methods. Recent data emerging from these approaches in combination with theoretical modeling led to novel ideas and significant revisions of the basic concepts in the field. In this Perspective, we discuss the advances in the understanding of spindle mechanics, focusing on microtubule forces that control chromosome movements.

Item Type: Article
Uncontrolled Keywords: mitotic spindle; microtubules; kinetochores; kinetochore fibers; bridging fibers; kinesins; forces; laser ablation; microneedle; theory; modeling
Subjects: NATURAL SCIENCES > Physics > Biophysics and Medical Physics
NATURAL SCIENCES > Biology > Biochemistry and Molecular Biology
Divisions: Division of Molecular Biology
Depositing User: Maša Sabo
Date Deposited: 04 Feb 2021 09:06
DOI: 10.1016/j.devcel.2020.11.003

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