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The Influence of Different Classes of Amino Acids on Calcium Phosphates Seeded Growth

Mihelj Josipović, Tea; Kovačević, Monika; Matešs, Sarah; Kostešić, Marina; Matijaković, Nives; Radatović, Borna; Lyons, Daniel M.; Kralj, Damir; Dutour Sikirić, Maja (2020) The Influence of Different Classes of Amino Acids on Calcium Phosphates Seeded Growth. Materials, 13 (21). ISSN 1996-1944

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Abstract

Amino acids (AAs) attract attention for elucidating the role of proteins in biomineralization and the preparation of functionalized biomaterials. The influence that AAs exert on calcium phosphate (CaP) mineralization is still not completely understood, as contradictory results have been reported. In this paper, the influence of the addition of different classes of AAs, charged (L-aspartic acid, Asp ; L-lysine, Lys), polar (L-asparagine, Asn ; L-serine, Ser ; L-tyrosine, Tyr), and non-polar (L-phenylalanine, Phe), on CaP growth in the presence of octacalcium phosphate (OCP) and calcium hydrogenphosphate dihydrate (DCPD) seeds was investigated. In control systems (without AAs), a calcium-deficient apatite (CaDHA) layer was formed on the surface of OCP, while a mixture of CaDHA and OCP in the form of spherical aggregates was formed on the surface of DCPD crystals. Charged and non-polar promoted, while polar AAs inhibited CaDHA formation on the OCP seeds. In the case of DCPD, Lys, Asp, and Phe promoted CaP formation, while the influence of other AAs was negligible. The most efficient promotor of precipitation in both cases was non-polar Phe. No significant influence of AAs on the composition and morphology of precipitates was observed. The obtained results are of interest for understanding biomineralization processes and additive controlled material synthesis.

Item Type: Article
Uncontrolled Keywords: octacalcium phosphate ; dicalcium hydrogenphosphate dihydrate ; amino acids ; biomineralization ; seeded growth
Subjects: NATURAL SCIENCES > Chemistry
Divisions: Division for Marine and Enviromental Research
Division of Materials Chemistry
Division of Physical Chemistry
Projects:
Project titleProject leaderProject codeProject type
Bioinspirirani materijali - mehanizmi nastajanja i interakcija-Bio-Mat-FormDamir KraljIP-2013-11-5055HRZZ
Depositing User: Damir Kralj
Date Deposited: 10 Nov 2020 10:44
Last Modified: 10 Nov 2020 10:44
URI: http://fulir.irb.hr/id/eprint/5989
DOI: 10.3390/ma13214798

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