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Differential Expression of TFF1 and TFF3 in Patients Suffering from Chronic Rhinosinusitis with Nasal Polyposis

Mihalj, Martina; Bujak, Maro; Butković, Josip; Zubčić, Željko; TolušiĆ Levak, Maja; Čes, Josip; Kopić, Vlatko; Baus Lončar, Mirela; Mihalj, Hrvoje (2019) Differential Expression of TFF1 and TFF3 in Patients Suffering from Chronic Rhinosinusitis with Nasal Polyposis. International journal of molecular sciences, 20 (21). ISSN 1661-6596

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Trefoil family factor (TFF) proteins contribute to antimicrobial defense and the maintenance of sinonasal epithelial barrier integrity. Dysregulation of TFF expression may be involved in the development of chronic inflammation and tissue remodeling characteristically found in chronic rhinosinusitis with nasal polyposis (CRSwNP). Expressions of TFF1 and TFF3 were determined in specimens of middle nasal turbinate (MNT-0), bulla ethmoidalis (BE), and nasal polyps (NP) from CRSwNP patients (n = 29) and inferior nasal turbinate from a group of control patients (underwent nasal septoplasty, n = 25). An additional MNT sample was collected 6 months after functional endoscopic sinus surgery (FESS, MNT-6). TFF1 mRNA levels were significantly reduced in all specimens by approximately three- to five-fold, while TFF3 was increased in MNT-0, as compared with controls. Six months after surgery their levels were reversed to control values. CRSwNP patients with S. epidermidis isolated from sinus swabs showed upregulation of TFF3 in MNT and NP as compared with patients with sterile swabs. Target gene regulation was not affected by the presence of type 2 inflammation in patients with confirmed allergy. Results of this study imply participation of TFFs genes in the development of CRSwNP.

Item Type: Article
Uncontrolled Keywords: chronic rhinosinusitis ; nasal polyposis ; trefoil factor family
Subjects: BIOMEDICINE AND HEALTHCARE > Basic Medical Sciences
BIOMEDICINE AND HEALTHCARE > Clinical Medical Sciences
Divisions: Division of Materials Chemistry
Project titleProject leaderProject codeProject type
TFF3 protein na raskrižju metabolizma i neurodegeneracije-Inter MeNe-3Mirela Baus LončarIP-2016-06-2717HRZZ
Uloga malih zaštitinih TFF proteina u zdravlju i bolesti-Tatjana Belovari219-0982914-2179MZOS
Depositing User: Mirela Baus Lončar
Date Deposited: 09 Nov 2020 13:52
DOI: 10.3390/ijms20215461

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