Organocatalytic Synthesis of α-Triphenylmethylamines from Diarylketimines and Phenols

Glavač, Danijel; Topolovčan, Nikola; Gredičak, Matija (2020) Organocatalytic Synthesis of α-Triphenylmethylamines from Diarylketimines and Phenols. The Journal of Organic Chemistry, 85 (21). pp. 14253-14261. ISSN 0022-3263

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Abstract

A formal Betti reaction between variously substituted phenols and benzophenone-derived imines to afford α-triphenylmethylamines is reported. The key to the success of this transformation is the in situ generation of the reactive benzophenone iminium species under organocatalytic conditions. Different phenols reacted smoothly, enabling the synthesis of an array of α-triphenylmethylamines, which are highly valued structural motifs in bioactive molecules and chemical sensors.

Item Type:	Article
Uncontrolled Keywords:	Hydrocarbons; Chemical reactions; Aromatic compounds
Subjects:	NATURAL SCIENCES NATURAL SCIENCES > Chemistry NATURAL SCIENCES > Chemistry > Organic Chemistry
Divisions:	Division of Organic Chemistry and Biochemistry
Projects:	Project title Project leader Project code Project type Nove Strategije Za Pripravu Tetrasupstituiranih Kiralnih Centara: Asimetrične Katalitičke Reakcije Usmjerene Protuanionom-NSYNC-ACDC Matija Gredičak IP-2018-01-4053 HRZZ
Depositing User:	Matija Gredičak
Date Deposited:	09 Nov 2020 13:43
URI:	http://fulir.irb.hr/id/eprint/5978
DOI:	10.1021/acs.joc.0c02225

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