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4-Hydroxynonenal in Redox Homeostasis of Gastrointestinal Mucosa: Implications for the Stomach in Health and Diseases

Cherkas, Andriy; Žarković, Neven (2018) 4-Hydroxynonenal in Redox Homeostasis of Gastrointestinal Mucosa: Implications for the Stomach in Health and Diseases. Antioxidants, 7 (9). ISSN 2076-3921

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Abstract

Maintenance of integrity and function of the gastric mucosa (GM) requires a high regeneration rate of epithelial cells during the whole life span. The health of the gastric epithelium highly depends on redox homeostasis, antioxidant defense, and activity of detoxifying systems within the cells, as well as robustness of blood supply. Bioactive products of lipid peroxidation, in particular, second messengers of free radicals, the bellwether of which is 4-hydroxynonenal (HNE), are important mediators in physiological adaptive reactions and signaling, but they are also thought to be implicated in the pathogenesis of numerous gastric diseases. Molecular mechanisms and consequences of increased production of HNE, and its protein adducts, in response to stressors during acute and chronic gastric injury, are well studied. However, several important issues related to the role of HNE in gastric carcinogenesis, tumor growth and progression, the condition of GM after eradication of Helicobacter pylori, or the relevance of antioxidants for HNE-related redox homeostasis in GM, still need more studies and new comprehensive approaches. In this regard, preclinical studies and clinical intervention trials are required, which should also include the use of state-of-the-art analytical techniques, such as HNE determination by immunohistochemistry and enzyme-linked immunosorbent assay (ELISA), as well as modern mass-spectroscopy methods.

Item Type: Article
Uncontrolled Keywords: 4-hydroxynonenal ; lipid peroxidation ; redox balance ; oxidative stress ; stomach ; peptic ulcer ; gastritis ; Helicobacter pylori ; gastric cancer ; non-steroid anti-inflammatory drugs-induced gastropathy
Subjects: NATURAL SCIENCES > Biology
NATURAL SCIENCES > Biology > Biochemistry and Molecular Biology
BIOMEDICINE AND HEALTHCARE > Basic Medical Sciences > Pharmacology
BIOMEDICINE AND HEALTHCARE > Pharmacy
Divisions: Division of Molecular Medicine
Depositing User: Neven Žarković
Date Deposited: 12 Mar 2020 14:52
Last Modified: 12 Mar 2020 14:52
URI: http://fulir.irb.hr/id/eprint/5339
DOI: 10.3390/antiox7090118

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