Synthesis of Novel, Potentially Biologically Active Dibenzosuberone Derivatives

Merkaš, Sonja; Litvić, Mladen; Cepanec, Ivica; Vinković, Vladimir (2005) Synthesis of Novel, Potentially Biologically Active Dibenzosuberone Derivatives. Molecules, 10 (12). pp. 1429-1437. ISSN 1420-3049

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Abstract

Novel representatives of the important group of biologically active dibenzosuberone derivatives were prepared, 3, 7-dibromo-5-(dimethylaminoethyl-oxyimino)-10, 11-dihydro-5H-dibenzo[a, d]cyclohepta-1, 4-diene (1), 3, 7-dibromo-5-(3-dimethylaminopropylidene)-10, 11-dihydro-5H-dibenzo[a, d]cycloheptene (2) and 1, 7-dibromo-5-(3-dimethylaminopropylidene)-10, 11-dihydro-5H-dibenzo[a, d]cycloheptene (3). These compounds are potential members of tricyclic antidepressants (TCAs), still in many countries the most frequently prescribed antidepressants.

Item Type:	Article
Uncontrolled Keywords:	Dibenzosuberone ; tricyclic antidepressants ; bromination ; amitryptiline ; noxiptiline
Subjects:	NATURAL SCIENCES > Chemistry
Divisions:	Division of Organic Chemistry and Biochemistry
Depositing User:	Vladimir Vinković
Date Deposited:	12 Feb 2020 12:02
URI:	http://fulir.irb.hr/id/eprint/5302
DOI:	10.3390/10121429

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