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Thymus Regeneration and Future Challenges

Antica, Mariastefania; Shichkin, Valentin (2020) Thymus Regeneration and Future Challenges. Stem Cell Reviews and Reports, 16 . pp. 239-250. ISSN 2629-3269

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Abstract

Thymus regenerative therapy implementation is severely obstructed by the limited number and expansion capacity in vitro of tissue-specific thymic epithelial stem cells (TESC). Current solutions are mostly based on growth factors that can drive differentiation of pluripotent stem cells toward tissue-specific TESC. Target-specific small chemical compounds represent an alternative solution that could induce and support the clonal expansion of TESC and reversibly block their differentiation into mature cells. These compounds could be used both in the composition of culture media designed for TESC expansion in vitro, and in drugs development for thymic regeneration in vivo. It should allow reaching the ultimate objective - autologous thymic tissue regeneration in paediatric patients who had their thymus removed in the course of cardiac surgery.

Item Type: Article
Uncontrolled Keywords: Stem cells ; Thymus ; Thymectomised patients ; Thymus regeneration ; Thymic epithelial stem cells ; Small chemical compounds
Subjects: NATURAL SCIENCES
NATURAL SCIENCES > Biology > Biochemistry and Molecular Biology
BIOMEDICINE AND HEALTHCARE
BIOMEDICINE AND HEALTHCARE > Basic Medical Sciences
BIOMEDICINE AND HEALTHCARE > Basic Medical Sciences > Immunology
BIOMEDICINE AND HEALTHCARE > Clinical Medical Sciences
BIOMEDICINE AND HEALTHCARE > Clinical Medical Sciences > Clinical Immunology
BIOTECHNICAL SCIENCES
BIOTECHNICAL SCIENCES > Biotechnology > Biology
Divisions: Division of Molecular Biology
Depositing User: Mariastefania Antica
Date Deposited: 03 Dec 2020 13:30
Last Modified: 03 Dec 2020 13:30
URI: http://fulir.irb.hr/id/eprint/5298
DOI: 10.1007/s12015-020-09955-y

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