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Phospholipid and Hydrocarbon Interactions with a Charged Electrode Interface

Levine, Z.A.; Ivošević DeNardis, Nadica; Vernier, P. Thomas (2016) Phospholipid and Hydrocarbon Interactions with a Charged Electrode Interface. Langmuir, 32 (11). pp. 2808-2819. ISSN 0743-7463

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Abstract

Using a combination of molecular dynamics simulations and experiments, we have examined the interactions of alkanes and phospholipids at charged interfaces in order to understand how interfacial charge densities affect the association of these two representative molecules with electrodes. Consistent with theory and experiment, these model systems reveal interfacial associations mediated through a combination of Coulombic and van der Waals forces. Van der Waals forces, in particular, mediate rapid binding of decane to neutral electrodes. No decane binding was observed at high surface charge densities because of interfacial water polarization, which screens hydrophobic attractions. The positively charged choline moiety of the phospholipid palmitoyloleoylphosphatidylcholine (POPC) is primarily responsible for POPC attraction by a moderately negatively-charged electrode. The hydrocarbon tails of POPC interact with the hydrophobic electrode interface similarly to decane. Previously reported electrochemical results confirm these findings by demonstrating bipolar displacement currents from PC vesicles adhering to moderately negatively-charged interfaces, originating from the choline interactions observed in simulations. At more negatively-charged interfaces, choline-to-surface binding was stronger. In both simulations and experiments the maximal interaction of anionic PS occurs with a positively charged interface, provided that the electrostatic forces outweigh local Lennard-Jones interactions. Direct comparisons between the binding affinities measured in experiments and those obtained in simulations reveal previously unobserved atomic interactions that facilitate lipid vesicle adhesion to charged interfaces. Moreover, the implementation of a charged interface in molecular dynamics simulations provides an alternative method for the generation of large electric fields across phospholipid bilayers, especially for systems with periodic boundary conditions, and may be useful for simulations of membrane electropermeabilization.

Item Type: Article
Uncontrolled Keywords: adhesion ; adsorption ; charged interface ; chronoamperometry ; lipid aggregation ; molecular dynamics simulations ; phospholipids
Subjects: NATURAL SCIENCES > Physics
Divisions: Division for Marine and Enviromental Research
Projects:
Project titleProject leaderProject codeProject type
Površinske sile na atomskoj skali u istraživanju mora i nanotehnologiji-Vesna Svetličić098-0982934-2744MZOS
Depositing User: Nadica Ivošević DeNardis
Date Deposited: 03 Jul 2019 08:48
Last Modified: 03 Jul 2019 08:48
URI: http://fulir.irb.hr/id/eprint/4638
DOI: 10.1021/acs.langmuir.5b04090

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