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Oleanolic Acid Alters Multiple Cell Signaling Pathways: Implication in Cancer Prevention and Therapy

Žiberna, Lovro; Šamec, Dunja; Mocan, Andrei; Nabavi, Seyed Fazel; Bishayee, Anupam; Farooqi, Ammad Ahmad; Sureda, Antoni; Nabavi, Seyed Mohammad (2017) Oleanolic Acid Alters Multiple Cell Signaling Pathways: Implication in Cancer Prevention and Therapy. International Journal of Molecular Sciences, 18 (3). ISSN 1661-6596

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Abstract

Nowadays much attention has been paid to diet and dietary supplements as a cost-effective therapeutic strategy for prevention and treatment of a myriad of chronic and degenerative diseases. Rapidly accumulating scientific evidence achieved through high-throughput technologies has greatly expanded the understanding about the multifaceted nature of cancer. Increasingly, it is being realized that deregulation of spatio-temporally controlled intracellular signaling cascades plays a contributory role in the onset and progression of cancer. Therefore, targeting regulators of oncogenic signaling cascades is essential to prevent and treat cancer. A plethora of preclinical and epidemiological evidences showed promising role of phytochemicals against several types of cancer. Oleanolic acid, a common pentacyclic triterpenoid, is mainly found in olive oil as well as several plant species. It is a potent inhibitor of cellular inflammatory process and a well-known inducer of phase 2 xenobiotic biotransformation enzymes. Targeting caspases, 5' adenosine monophosphate-activated protein kinase, extracellular signal–regulated kinase 1/2, matrix metalloproteinases, pro-apoptotic Bax and bid, phosphatidylinositide 3-kinase/Akt1/mechanistic target of rapamycin, reactive oxygen species/apoptosis signal-regulating kinase 1/p38 mitogen-activated protein kinase, nuclear factor-B, cluster of differentiation 1, CKD4, s6k, signal transducer and activator of transcription 3 as well as aforementioned signaling pathways may act as main molecular mechanisms underlying anticancer effects of oleanolic acid. In this work, we critically review the scientific literature on the molecular targets of oleanolic acid implicated in prevention and treatment of several types of cancer. We also discuss chemical aspects, natural sources, bioavailability, and safety of this bioactive phytochemical.

Item Type: Article
Uncontrolled Keywords: oleanolic acid ; olive ; anticancer effect ; signaling pathways
Subjects: NATURAL SCIENCES > Biology
Divisions: Division of Molecular Biology
Depositing User: Dunja Šamec
Date Deposited: 13 Jun 2019 11:53
Last Modified: 13 Jun 2019 11:53
URI: http://fulir.irb.hr/id/eprint/4564
DOI: 10.3390/ijms18030643

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