The Influence of alpha-, beta-, and gamma-Melanocyte Stimulating Hormone on Acetaminophen Induced Liver Lesions in Male CBA Mice

Blagaić, Vladimir; Houra, Karlo; Turčić, Petra; Štambuk, Nikola; Konjevoda, Paško; Boban-Blagaić, Alenka; Kelava, Tomislav; Kos, Marina; Aralica, Gorana; Čulo, Filip (2010) The Influence of alpha-, beta-, and gamma-Melanocyte Stimulating Hormone on Acetaminophen Induced Liver Lesions in Male CBA Mice. Molecules, 15 (3). pp. 1232-1245. ISSN 1420-3049

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Official URL: https://doi.org/10.3390/molecules15031232

Abstract

Research over the past decade has indicated that melanocortin peptides are potent inhibitors of inflammation and a promising source of new anti-inflammatory andcytoprotective therapies. The purpose of the present paper is to compare protective effects of α-, β-, and γ-melanocyte stimulating hormone on acetaminophen induced liver lesions in male CBA mice. Acetaminophen was applied intragastrically in a dose of 150 mg/kg, and tested substances were applied intraperitoneally 1 hour before acetaminophen. Mice were sacrificed after 24 hours and intensity of liver injury was estimated by measurement of plasma transaminase activity (AST and ALT) and histopathological grading of lesions. It was found that α-, β-, and γ-MSH decrease intensity of lesions by both criteria in a dosedependent manner.

Item Type:

Article

Uncontrolled Keywords:

melanocortins ; alpha-MSH ; beta-MSH ; gamma-MSH ; acetaminophen ; liver

Subjects:

NATURAL SCIENCES > Chemistry

Divisions:

NMR Center

Projects:

Project title	Project leader	Project code	Project type
ENDEMSKA NEFROPATIJA U HRVATSKOJ, epidemiologija, dijagnostika i etiopatogeneza-	Bojan Jelaković	108-0000000-0329	MZOS
Modeliranje bioaktivnih molekula i ispitivanje njihovih svojstava i učinka-	Nikola Štambuk	098-0982929-2524	MZOS

Depositing User:

Paško Konjevoda

Date Deposited:

18 Feb 2019 10:16

URI:

http://fulir.irb.hr/id/eprint/4423

DOI:

10.3390/molecules15031232