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The Influence of alpha-, beta-, and gamma-Melanocyte Stimulating Hormone on Acetaminophen Induced Liver Lesions in Male CBA Mice

Blagaić, Vladimir; Houra, Karlo; Turčić, Petra; Štambuk, Nikola; Konjevoda, Paško; Boban-Blagaić, Alenka; Kelava, Tomislav; Kos, Marina; Aralica, Gorana; Čulo, Filip (2010) The Influence of alpha-, beta-, and gamma-Melanocyte Stimulating Hormone on Acetaminophen Induced Liver Lesions in Male CBA Mice. Molecules, 15 (3). pp. 1232-1245. ISSN 1420-3049

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Abstract

Research over the past decade has indicated that melanocortin peptides are potent inhibitors of inflammation and a promising source of new anti-inflammatory andcytoprotective therapies. The purpose of the present paper is to compare protective effects of α-, β-, and γ-melanocyte stimulating hormone on acetaminophen induced liver lesions in male CBA mice. Acetaminophen was applied intragastrically in a dose of 150 mg/kg, and tested substances were applied intraperitoneally 1 hour before acetaminophen. Mice were sacrificed after 24 hours and intensity of liver injury was estimated by measurement of plasma transaminase activity (AST and ALT) and histopathological grading of lesions. It was found that α-, β-, and γ-MSH decrease intensity of lesions by both criteria in a dosedependent manner.

Item Type: Article
Uncontrolled Keywords: melanocortins ; alpha-MSH ; beta-MSH ; gamma-MSH ; acetaminophen ; liver
Subjects: NATURAL SCIENCES > Chemistry
Divisions: NMR Center
Projects:
Project titleProject leaderProject codeProject type
ENDEMSKA NEFROPATIJA U HRVATSKOJ, epidemiologija, dijagnostika i etiopatogeneza-Bojan Jelaković108-0000000-0329MZOS
Modeliranje bioaktivnih molekula i ispitivanje njihovih svojstava i učinka-Nikola Štambuk098-0982929-2524MZOS
Depositing User: Paško Konjevoda
Date Deposited: 18 Feb 2019 10:16
Last Modified: 18 Feb 2019 14:41
URI: http://fulir.irb.hr/id/eprint/4423
DOI: 10.3390/molecules15031232

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