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DNA–Protein Crosslink Proteolysis Repair

Vaz, Bruno; Popović, Marta; Ramadan, Kristijan (2017) DNA–Protein Crosslink Proteolysis Repair. Trends in Biochemical Sciences, 42 (6). pp. 483-495. ISSN 0968-0004

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Proteins that are covalently bound to DNA constitute a specific type of DNA lesion known as DNA–protein crosslinks (DPCs). DPCs represent physical obstacles to the progression of DNA replication. If not repaired, DPCs cause stalling of DNA replication forks that consequently leads to DNA double-strand breaks, the most cytotoxic DNA lesion. Although DPCs are common DNA lesions, the mechanism of DPC repair was unclear until now. Recent work unveiled that DPC repair is orchestrated by proteolysis performed by two distinct metalloproteases, SPARTAN in metazoans and Wss1 in yeast. This review summarizes recent discoveries on two proteases in DNA replication-coupled DPC repair and establishes DPC proteolysis repair as a separate DNA repair pathway for genome stability and protection from accelerated aging and cancer.

Item Type: Article
Uncontrolled Keywords: aging; cancer; DNA–protein crosslink; DNA–protein crosslink proteolysis repair; DNA replication; genome stability; SPARTAN (DVC1) protease; Wss1 protease
Subjects: NATURAL SCIENCES > Biology
NATURAL SCIENCES > Biology > Biochemistry and Molecular Biology
Divisions: Division for Marine and Enviromental Research
Depositing User: Marta Popović
Date Deposited: 25 Oct 2018 14:10
DOI: 10.1016/j.tibs.2017.03.005

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