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Role of GLI Transcription Factors in Pathogenesis and Their Potential as New Therapeutic Targets

Sabol, Maja; Trnski, Diana; Musani, Vesna; Ozretić, Petar; Levanat, Sonja (2018) Role of GLI Transcription Factors in Pathogenesis and Their Potential as New Therapeutic Targets. International journal of molecular sciences, 19 (9). ISSN 1422-0067

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Abstract

GLI transcription factors have important roles in intracellular signaling cascade, acting as the main mediators of the HH-GLI signaling pathway. This is one of the major developmental pathways, regulated both canonically and non-canonically. Deregulation of the pathway during development leads to a number of developmental malformations, depending on the deregulated pathway component. The HH-GLI pathway is mostly inactive in the adult organism but retains its function in stem cells. Aberrant activation in adult cells leads to carcinogenesis through overactivation of several tightly regulated cellular processes such as proliferation, angiogenesis, EMT. Targeting GLI transcription factors has recently become a major focus of potential therapeutic protocols.

Item Type: Article
Uncontrolled Keywords: HH-GLI signaling pathway ; GLI transcription factors ; signal transduction ; malformations ; cancer ; therapy
Subjects: BIOMEDICINE AND HEALTHCARE > Basic Medical Sciences
Divisions: Division of Molecular Medicine
Projects:
Project titleProject leaderProject codeProject type
Novi molekularni mehanizmi kao mete ciljanih terapija: Interakcije molekula mikroRNA i signalnog puta Hedgehog-GLI u seroznom karcinomu jajnika-MIRnaGLISonja LevanatIP-2016-06-1268HRZZ
UNSPECIFIEDUNSPECIFIEDGrad Zagreb URBROJ: 251-03-02-15-2UNSPECIFIED
Depositing User: Sofija Konjević
Date Deposited: 04 Sep 2018 13:17
Last Modified: 04 Sep 2018 13:17
URI: http://fulir.irb.hr/id/eprint/4165
DOI: 10.3390/ijms19092562

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