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Organocatalytic asymmetric transformations of 3–substituted 3–hydroxyisoindolinones

Glavač, Danijel; Gredičak, Matija (2017) Organocatalytic asymmetric transformations of 3–substituted 3–hydroxyisoindolinones. SYNLETT, 28 (8). pp. 889-897. ISSN 0936-5214

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This Account provides an overview of our group's research in the field of asymmetric organocatalytic transformations generating chiral isoindolinone cores. We describe the synthesis of 3–substituted 3–hydroxyisoindolinones, starting materials for these transformations, comprising a wide range of functional groups, as well as their utilization in asymmetric transformations. We also discuss our efforts in the application of the developed methodology in the synthesis of a known HIV–1 Inhibitor.

Item Type: Article
Additional Information: The financial support for the presented work was provided by the Abbvie-Croatian Science Foundation Young Researcher Grant 2015, and by the Croatian Academy of Sciences and Arts. We would like to thank Dr. Irena Dokli and Dr. Josipa Suc for making significant contributions to these projects.
Uncontrolled Keywords: organocatalytic asymmetric transformation; 3–hydroxyisoindolinones; chiral Brønsted acid; isoindolinone core; organometallic addition; chiral N,S–acetals
Subjects: NATURAL SCIENCES > Chemistry > Organic Chemistry
Divisions: Division of Organic Chemistry and Biochemistry
Project titleProject leaderProject codeProject type
Abbvie/HRZZMatija GredičakUNSPECIFIEDznanstveni
Depositing User: Matija Gredičak
Date Deposited: 12 Jan 2018 13:25
DOI: 10.1055/s-0036-1588759

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