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Synthesis, characterization and in vitro biocompatibility assessment of a novel tripeptide hydrogelator, as a promising scaffold for tissue engineering applications

Pospišil, Tihomir; Ferhatović Hamzić, Lejla; Brkić Ahmed, Lada; Lovrić, Marija; Gajović, Srećko; Frkanec, Leo (2016) Synthesis, characterization and in vitro biocompatibility assessment of a novel tripeptide hydrogelator, as a promising scaffold for tissue engineering applications. Biomaterials Science, 4 (10). pp. 1412-1416. ISSN 2047-4830

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Abstract

We have synthesized and characterized a self- assembling tripeptide hydrogelator Ac-L-Phe-L- Phe-L-Ala-NH2. A series of experiments showed that the hydrogel material could serve as a stabile and biocompatible physical support as it improves the survival of HEK293T cells in vitro, thus being a promising biomaterial for use in tissue engineering applications.

Item Type: Article
Additional Information: This work was supported by the Ministry of Science, Education and Sports of the Republic of Croatia, the Croatian Science Foundation (HRZZ project IP-11-2013-7387), and EU FP7 Glow-Brain project (REGPOT-2012-CT2012-316120). The authors thank Dr Hrvoje Banfic (Croatian Institute for Brain Research, University of Zagreb, School of Medicine, Zagreb) for providing HEK293T cells. We greatly acknowledge the access to the equipment in possession of the University of Rijeka within the project RISK "Development of University of Rijeka campus laboratory research infrastructure", financed by the European Regional Development Fund (ERDF) supported by a EU FP7 grant, and particularly Dr Karlo Wittine and Dr Uros Andelkovic for providing HRMS spectra.
Uncontrolled Keywords: supramolecular self-assembly ; peptide hydrogelator ; biomaterials ; tissue engineering ;
Subjects: NATURAL SCIENCES > Chemistry
NATURAL SCIENCES > Chemistry > Organic Chemistry
NATURAL SCIENCES > Biology > Biochemistry and Molecular Biology
BIOMEDICINE AND HEALTHCARE > Basic Medical Sciences
Divisions: Division of Organic Chemistry and Biochemistry
Projects:
Project titleProject leaderProject codeProject type
Supramolekulska sinteza samo-organizirajućih funkcionalnih nanomaterijala i kompleksnih kemijskih sustavaLeo FrkanecHRZZ-IP-2013-11-7387HrZZ
EU FP7 Glow-Brain projectUNSPECIFIEDREGPOT–2012–CT2012–316120UNSPECIFIED
UNSPECIFIEDUNSPECIFIEDEuropean Regional Development Fund (ERDF) - EU FP7 grantUNSPECIFIED
Depositing User: Leo Frkanec
Date Deposited: 06 Dec 2017 12:34
Last Modified: 06 Dec 2017 12:34
URI: http://fulir.irb.hr/id/eprint/3712
DOI: 10.1039/C6BM00287K

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