Synthesis, characterization and in vitro biocompatibility assessment of a novel tripeptide hydrogelator, as a promising scaffold for tissue engineering applications

Pospišil, Tihomir; Ferhatović Hamzić, Lejla; Brkić Ahmed, Lada; Lovrić, Marija; Gajović, Srećko; Frkanec, Leo (2016) Synthesis, characterization and in vitro biocompatibility assessment of a novel tripeptide hydrogelator, as a promising scaffold for tissue engineering applications. Biomaterials Science, 4 (10). pp. 1412-1416. ISSN 2047-4830

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Official URL: http://pubs.rsc.org/en/content/articlelanding/2016...

Abstract

We have synthesized and characterized a self- assembling tripeptide hydrogelator Ac-L-Phe-L- Phe-L-Ala-NH2. A series of experiments showed that the hydrogel material could serve as a stabile and biocompatible physical support as it improves the survival of HEK293T cells in vitro, thus being a promising biomaterial for use in tissue engineering applications.

Item Type:

Article

Additional Information:

This work was supported by the Ministry of Science, Education and Sports of the Republic of Croatia, the Croatian Science Foundation (HRZZ project IP-11-2013-7387), and EU FP7 Glow-Brain project (REGPOT-2012-CT2012-316120). The authors thank Dr Hrvoje Banfic (Croatian Institute for Brain Research, University of Zagreb, School of Medicine, Zagreb) for providing HEK293T cells. We greatly acknowledge the access to the equipment in possession of the University of Rijeka within the project RISK "Development of University of Rijeka campus laboratory research infrastructure", financed by the European Regional Development Fund (ERDF) supported by a EU FP7 grant, and particularly Dr Karlo Wittine and Dr Uros Andelkovic for providing HRMS spectra.

Uncontrolled Keywords:

supramolecular self-assembly ; peptide hydrogelator ; biomaterials ; tissue engineering ;

Subjects:

NATURAL SCIENCES > Chemistry
NATURAL SCIENCES > Chemistry > Organic Chemistry
NATURAL SCIENCES > Biology > Biochemistry and Molecular Biology
BIOMEDICINE AND HEALTHCARE > Basic Medical Sciences

Divisions:

Division of Organic Chemistry and Biochemistry

Projects:

Project title	Project leader	Project code	Project type
Supramolekulska sinteza samo-organizirajućih funkcionalnih nanomaterijala i kompleksnih kemijskih sustava	Leo Frkanec	HRZZ-IP-2013-11-7387	HrZZ
EU FP7 Glow-Brain project	UNSPECIFIED	REGPOT–2012–CT2012–316120	UNSPECIFIED
UNSPECIFIED	UNSPECIFIED	European Regional Development Fund (ERDF) - EU FP7 grant	UNSPECIFIED