Molecular stratification of colorectal cancer

Kapitanović, Sanja (2015) Molecular stratification of colorectal cancer. Rad Hrvatske akademije znanosti i umjetnosti. Medicinske znanosti, 522 . pp. 107-115. ISSN 1330-5301

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Abstract

Colorectal cancer (CRC) is one of the most common cancers and one of the leading causes of cancer death in the Western world. The disease arises from the accumulation of mutations in oncogenes, tumor suppressor genes and mismatch repair genes during progression from normal colon epithelium to adenoma and metastatic carcinoma. Improved understanding of genetic events that underline tumor development and progression may contribute to new strategies for prevention, diagnosis as well as for therapy. The results of Human genome project showed that each person has its unique genetic “signature” as a consequence of a large number of inherited genetic variations. There are also sporadic molecular changes specific for each tumor type. This mini review will give some information about the most frequent molecular genetics changes in colorectal cancer and its molecular stratification due to its heredity, germline pharmacogenetic markers, somatic mutations and microsatellite instability.

Item Type:	Article
Uncontrolled Keywords:	colorectal cancer ; biomarkers ; molecular stratification
Subjects:	BIOMEDICINE AND HEALTHCARE > Basic Medical Sciences BIOMEDICINE AND HEALTHCARE > Clinical Medical Sciences
Divisions:	Division of Molecular Medicine
Depositing User:	Sanja Kapitanović
Date Deposited:	05 Sep 2017 12:46
URI:	http://fulir.irb.hr/id/eprint/3550

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