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Advanced glycoxidation and lipoxidation end products (AGEs and ALEs): an overview of their mechanisms of formation

Vistoli, G.; De Maddis, D.; Čipak Gašparović, Ana; Žarković, Neven; Carini, M.; Aldini, G. (2013) Advanced glycoxidation and lipoxidation end products (AGEs and ALEs): an overview of their mechanisms of formation. Free Radical Research, 47 (S1). pp. 3-27. ISSN 1071-5762

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Advanced lipoxidation end products (ALEs) and advanced glycation end products (AGEs) have a pathogenetic role in the development and progression of different oxidative-based diseases including diabetes, atherosclerosis, and neurological disorders. AGEs and ALEs represent a quite complex class of compounds that are formed by different mechanisms, by heterogeneous precursors and that can be formed either exogenously or endogenously. There is a wide interest in AGEs and ALEs involving different aspects of research which are essentially focused on set-up and application of analytical strategies (1) to identify, characterize, and quantify AGEs and ALEs in different pathophysiological conditions ; (2) to elucidate the molecular basis of their biological effects ; and (3) to discover compounds able to inhibit AGEs/ALEs damaging effects not only as biological tools aimed at validating AGEs/ALEs as drug target, but also as promising drugs. All the above-mentioned research stages require a clear picture of the chemical formation of AGEs/ALEs but this is not simple, due to the complex and heterogeneous pathways, involving different precursors and mechanisms. In view of this intricate scenario, the aim of the present review is to group the main AGEs and ALEs and to describe, for each of them, the precursors and mechanisms of formation.

Item Type: Article
Uncontrolled Keywords: advanced glycation end products ; advanced lipoxidation end products ; AGEs ; ALEs ; protein carbonylation ; reactive carbonyls species
Subjects: NATURAL SCIENCES > Chemistry
NATURAL SCIENCES > Biology > Biochemistry and Molecular Biology
Divisions: Division of Molecular Medicine
Project titleProject leaderProject codeProject type
Lipidi, slobodni radikali i njihovi glasnici u integrativnoj onkologiji-Neven ZARKOVIC098-0982464-2519MZOS
Depositing User: Neven Žarković
Date Deposited: 25 Aug 2017 11:59
DOI: 10.3109/10715762.2013.815348

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