Milković, Lidija; Žarković, Neven; Saso, Luciano (2017) Controversy about pharmacological modulation of Nrf2 for cancer therapy. Redox Biology, 12 . pp. 727-732. ISSN 2213-2317
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Abstract
Conventional anticancer therapies such as radiotherapy and chemotherapies are associated with oxidative stress generating reactive oxygen species (ROS) and reactive aldehydes like 4-hydroxynonenal in cancer cells that govern them to die. The main mechanism activated due to exposure of the cell to these reactive species is the Nrf2-Keap1 pathway. Although Nrf2 was firstly perceived as a tumor suppressor that inhibits tumor initiation and cancer metastasis, more recent data reveal its role also as a pro-oncogenic factor. Discovery of the upregulation of Nrf2 in different types of cancer supports such undesirable pathophysiological roles of Nrf2. The upregulation of Nrf2 leads to activation of cytoprotective genes thus helping malignant cells to withstand high levels of ROS and to avoid apoptosis, eventually becoming resistant to conventional anticancer therapy. Therefore, new treatment strategies are needed for eradication of cancer and in this review, we will explore two opposing approaches for modulation of Nrf2 in cancer treatments.
| Item Type: | Article | ||||||||
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| Uncontrolled Keywords: | cancer; nrf2 ; oxidative stress; cancer therapy; growth regulation; 4-hydroxynonenal | ||||||||
| Subjects: | BIOMEDICINE AND HEALTHCARE BIOMEDICINE AND HEALTHCARE > Pharmacy > Medical Biochemistry |
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| Divisions: | Division of Molecular Medicine | ||||||||
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| Depositing User: | Lidija Milković | ||||||||
| Date Deposited: | 09 Aug 2017 10:04 | ||||||||
| URI: | http://fulir.irb.hr/id/eprint/3518 | ||||||||
| DOI: | 10.1016/j.redox.2017.04.013 |
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