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Does the Serum Metallothionein Level Reflect the Stage of Testicular Germ Cell Tumor?

Tariba, Blanka; Živković, Tanja; Filipović Marijić, Vlatka; Erk, Marijana; Gamulin, Marija; Pizent, Alica (2016) Does the Serum Metallothionein Level Reflect the Stage of Testicular Germ Cell Tumor?. Archives of Medical Research, 47 . pp. 232-235. ISSN 0188-4409

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Increased levels of metallothionein (MT) have recently been found in the blood serum of men with newly diagnosed testicular germ cell tumors (TGCT). In light of previously published results, the aim of this study was to investigate the difference in serum MT levels among patients with different stages of TGCT and compare MT with commonly used markers (α- fetoprotein, β-human chorionic gonadotropin and lactate dehydrogenase). The concentration of total MT was determined in the serum of 25 men with TGCT (seminoma or non-seminoma) by differential pulse voltammetry. Serum samples were obtained prior to chemotherapy, after two cycles of chemotherapy and 1 year after chemotherapy. A statistically significant difference in MT levels in patients with different stages of TGCT was observed in the serum of patients with non-seminoma obtained before chemotherapy. Although not significant, an increase in serum MT levels commensurate with the disease stage increase was also observed in patients with seminomatous TGCT. The results indicate that, in combination with the existing markers, MT could be useful for the identification of the histological type of tumor and stage of the disease before biopsy diagnosis.

Item Type: Article
Additional Information: This research was supported by the Croatian Ministry of Science, Education and Sports (Grant Number 022-0222411-2408).
Uncontrolled Keywords: Metallothionein; Non-seminoma; Seminoma; Serum marker; Testicular germ cell tumor
Subjects: BIOMEDICINE AND HEALTHCARE > Public Health and Health Care
Divisions: Division for Marine and Enviromental Research
Project titleProject leaderProject codeProject type
Učinci toksičnih i esencijalnih metala na reprodukcijsko zdravlje muškaraca-Alica Pizent022-0222411-2408MZOS
Depositing User: Vlatka Filipović Marijić
Date Deposited: 03 Sep 2020 08:55
DOI: 10.1016/j.arcmed.2016.05.005

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