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Human papillomavirus status in extragenital nonmelanoma skin cancers

Ledić Drvar, Daniela; Lipozenčić, Jasna; Sabol, Ivan; Bukvić Mokos, Zrinka; Ilić, Ivana; Grce, Magdalena (2014) Human papillomavirus status in extragenital nonmelanoma skin cancers. Clinics in Dermatology, 32 (2). pp. 248-252. ISSN 0738-081X

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Abstract

About 5% of all cancers worldwide can be attributed to human papillomaviruses (HPVs) ; namely, six sites are strongly associated with HPV infections: cervix, penis, vulva, vagina, anus, and oropharynx. Nonmelanoma skin cancers (NMSC), basal cell carcinoma (BCC), and squamous cell carcinoma (SCC) are the most common malignancies in Caucasians. In fact, there is an intense connection between sunlight exposure, fair skin, HPV, and development of NMSC. We have conducted a pilot study that included tissue samples from 26 carcinoma patients, of which there were 13 BCC and 13 SCC. HPV detection and typing was done with DNA amplification and sequencing, respectively. In total, 23.1% of SCC samples (3/13) and 7.7% of BCC samples (1/13) were positive for HPV DNA. The importance of understanding all aspects of NMSC carcinogenesis may be to reveal novel therapeutic options or preventive measures for HPV containing NMSC patients.

Item Type: Article
Uncontrolled Keywords: Human papillomavirus; basal cell carcinoma; squamous cell carcinoma
Subjects: BIOMEDICINE AND HEALTHCARE > Clinical Medical Sciences
BIOMEDICINE AND HEALTHCARE > Clinical Medical Sciences > Dermatovenerology
Divisions: Division of Molecular Medicine
Depositing User: Ivan Sabol
Date Deposited: 16 Nov 2016 16:09
Last Modified: 16 Nov 2016 16:09
URI: http://fulir.irb.hr/id/eprint/3125
DOI: 10.1016/j.clindermatol.2013.08.009

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