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HPV prevalence and p16INKa overexpression in non-smoking non-drinking oral cavity cancer patients

Dediol, Emil; Sabol, Ivan; Virag, Mišo; Grce, Magdalena; Muller, Danko; Manojlović, Spomenka (2016) HPV prevalence and p16INKa overexpression in non-smoking non-drinking oral cavity cancer patients. Oral Diseases, 22 (6). pp. 517-522. ISSN 1354-523X

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Abstract

Objective Our aim was to compare HPV and p16INK4a (p16) expression and their influence on survival and prognosis in oral cavity squamous cell cancer (OCSCC), between non-smokers and non-drinkers (NSND) and smokers and drinkers (SD). Subjects and Methods Patients with OCSCC treated with surgery from 2000 to 2010 were included in the study. Patients who did not smoke at all or smoked less than 10 pack per years and did not drink alcohol on a daily basis were considered the NSND group. An equal number of SD were the control group. HPV presence was determined from paraffin-embedded blocks investigated by PCR analysis. p16 expression was evaluated with immunohistochemistry. Results The NSND group were mostly younger or older female patients with tongue or gingival cancers. p16 expression was significantly more frequent in NSND patients (27% vs 10%). Patients with stronger p16 expression had significantly worse survival, especially for tongue cancers (P = 0.026). In Cox multivariate analysis, both HPV and p16 expression carried a negative prognosis for NSND patients (P = 0.0351 and P = 0.0260). Conclusions NSND are a specific population of OCSCC patients. In contrast to oropharyngeal cancer, HPV and p16 expression in OCSCC are negative predictive factors, especially in NSND patients.

Item Type: Article
Uncontrolled Keywords: Oral cancer; human papillomavirus (HPV); p16INK4a; non smoker; non drinker; tongue cancer
Subjects: BIOMEDICINE AND HEALTHCARE > Clinical Medical Sciences
BIOMEDICINE AND HEALTHCARE > Clinical Medical Sciences > Oncology
Divisions: Division of Molecular Medicine
Depositing User: Ivan Sabol
Date Deposited: 16 Nov 2016 16:04
Last Modified: 16 Nov 2016 16:46
URI: http://fulir.irb.hr/id/eprint/3123
DOI: 10.1111/odi.12476

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