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Pathogenesis, modulation, and therapy of Alzheimer’s disease: A perspective on roles of liver-X receptors

Štefulj, Jasminka; Panzenboeck, Ute; Hof, Patrick R.; Šimić, Goran (2013) Pathogenesis, modulation, and therapy of Alzheimer’s disease: A perspective on roles of liver-X receptors. Translational Neuroscience, 4 (3). pp. 349-356. ISSN 2081-3856

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Abstract

The pathogenesis of Alzheimer’s disease (AD) has been mostly linked to aberrant amyloid beta (Aβ) and tau proteins metabolism, disturbed lipid/cholesterol homeostasis, and progressive neuroinflammation. Liver X receptors (LXR) are ligand-activated transcription factors, best known as the key regulators of cholesterol metabolism and transport. In addition, LXR signaling has been shown to have significant anti-inflammatory properties. In this brief review, we focus on the outcome of studies implicating LXR in the pathogenesis, modulation, and therapy of AD.

Item Type: Article
Uncontrolled Keywords: Alzheimer’s disease; Neurodegeneration; Amyloid-beta; Cholesterol; Liver-X receptors; LXR agonists; Neuroinflammation; Transgenic mouse models
Subjects: NATURAL SCIENCES > Biology
BIOMEDICINE AND HEALTHCARE > Basic Medical Sciences
Divisions: Division of Molecular Biology
Projects:
Project titleProject leaderProject codeProject type
Otkrivanje i praćenje bioloških biljega radi rane terapijske intervencije u Alzheimerovoj bolesti-Goran ŠimićIS-09/16HRZZ
Serotonergična neurotransmisija: geni, proteini i ponašanje-Jasminka Štefulj098-1081870-2395MZOS
Fosforilacija tau proteina u razvitku i Alzheimerovoj bolesti-Goran Šimić108-1081870-1942MZOS
Depositing User: Jasminka Štefulj
Date Deposited: 16 Sep 2016 11:48
Last Modified: 05 May 2017 08:51
URI: http://fulir.irb.hr/id/eprint/3049
DOI: 10.2478/s13380-013-0136-z

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