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Immune thrombocytopenia: serum cytokines level in children and adults

Čulić, Srđana; Salamurić, Ilza; Konjevoda, Paško; Dajak, Slavica; Pavelić, Jasminka (2013) Immune thrombocytopenia: serum cytokines level in children and adults. Medical Science Monitor, 19 . pp. 797-801. ISSN 1234-1010

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Abstract

Immune thrombocytopenia (ITP) is an immune-mediated platelet disorder in which autoantibody-coated platelets are removed from the blood by monocytic phagocytes. The cytokines balance is well-known to regulate the immune system under normal condition, and is known to be impaired in many autoimmune diseases. This study was designed to investigate the role and imbalance of Th cytokines in the pathogenesis of ITP. The differences in cytokines level between pediatric and adult newly diagnosed patients with ITP was evaluated, and these profiles were compared to those found in healthy, age-matched controls. The concentration of IL-1α, IL-2, IL-3, IL-4, IL-6, IL-10, TNF-, IFN-, and IFN- in serum specimens was analyzed by enzyme linked immunosorbent assay. At the time of ITP diagnosis, children showed significantly lower serum levels of interleukin IL-2 and tumor necrosis factor TNF-α and higher serum level of IL-4 than healthy, controls. Serum level of IL-4 in adult ITP patients was higher than those in control subjects. When compared with adults, children with ITP had lower serum level of IL-4, IL-6 and IFN-γ, and higher level of IFN-α. The finding of significant differences in serum cytokine levels between patients and healthy controls supports the hypothesis that cytokine disturbances – especially changes in IL-4 – are involved in the pathogenesis of newly diagnosed ITP in both pediatric and adult patients.

Item Type: Article
Uncontrolled Keywords: immune thrombocytopenia; serum cytokine levels; children, adults
Subjects: BIOMEDICINE AND HEALTHCARE > Basic Medical Sciences
Divisions: Division of Molecular Medicine
Projects:
Project titleProject leaderProject codeProject type
Gensko liječenje tumora djelovanjem na molekule imunološkog sustava-Jasminka Pavelić098-0982464-2394MZOS
Modeliranje bioaktivnih molekula i ispitivanje njihovih svojstava i učinka-Nikola Štambuk098-0982929-2524MZOS
Depositing User: Paško Konjevoda
Date Deposited: 07 Sep 2016 14:47
Last Modified: 07 Sep 2016 14:47
URI: http://fulir.irb.hr/id/eprint/3038
DOI: 10.12659/MSM.884017

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