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Synthesis and biological activity of new diazenedicarboxamides as potential anticancer agents

Vajs, Jure; Soviček, Sanja; Kureljak, Petra; Stojanović, Nikolina; Steiner, Ivana; Eljuga, Domagoj; Urankar, Damijana; Kočevar, Marijan; Košmrlj, Janez; Polanc, Slovenko; Osmak, Maja (2013) Synthesis and biological activity of new diazenedicarboxamides as potential anticancer agents. Acta Chimica Slovenica, 60 (4). pp. 842-852. ISSN 1318-0207

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Abstract

To increase the effectiveness of cancer treatment, more effective anti-cancer drugs, as well as the new improved strategies of cancer treatment, are urgently needed. Our previous results have shown that various diazenes are cytotoxic to different tumor cells and can even revert the resistance to cisplatin and vincristine. We also demonstrated that unsymmetrical diazenedicarboxamides 1 and 2 exhibited promising cytotoxicity. The aim of the present study was to synthesize new diazenedicarboxamides with acceptable solubility and good cytotoxicity. Here we report the synthesis and biological evaluation of new N, N’-disubstituted diazenedicarboxamides. We found that a modification of either 1 or 2 led to the more active compounds. The most effective among them was diazenedicarboxamide 11, which can be considered as a new potential anticancer agent for the tumors of different origin, as well as for the drug resistant tumors.

Item Type: Article
Uncontrolled Keywords: diazenedicarboxamides; tumor cells; anticancer drugs
Subjects: NATURAL SCIENCES > Biology
NATURAL SCIENCES > Biology > Biochemistry and Molecular Biology
Divisions: Division of Molecular Biology
Projects:
Project titleProject leaderProject codeProject type
Stanični odgovor na citotoksične spojeve i razvoj otpornostiMaja Osmak098-0982913-2748MZOS
Povećanje transdukcije adenovirusnih vektora i otpornost stanica na citostatikeAndreja Ambriović Ristov098-0982913-2850MZOS
Depositing User: Nikolina Stojanović
Date Deposited: 21 Jul 2016 12:31
Last Modified: 21 Jul 2016 12:31
URI: http://fulir.irb.hr/id/eprint/2970

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