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Antineoplastic DNA-binding compounds: intercalating and minor groove binding drugs

Mišković, Katarina; Bujak, Maro; Baus Lončar, Mirela; Glavaš-Obrovac, Ljubica (2013) Antineoplastic DNA-binding compounds: intercalating and minor groove binding drugs. Arhiv za Higijenu Rada i Toksikologiju, 64 . pp. 593-602. ISSN 1848-6312

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DNA intercalating and minor groove binding compounds are new weapons in the battle against malignant diseases. These antineoplastic agents target the DNA molecule and interfere with the cell cycle leading to rapidly proliferating cell death. They are mainly derivates of a naturally occurring organic compound derived from a microorganism or plant. Intercalators usually act as topoisomerase I and/or II poisons, while the mechanisms of DNA minor groove binders are a combination of several steps including topoisomerase poisoning. This paper gives an overview of some of the developed DNA intercalating and minor groove binding compounds, as well as an explanation of their chemical structures, origins, and application in chemotherapy.

Item Type: Article
Uncontrolled Keywords: chemotherapy; DNA intercalator; DNA minor groove binder; organic compounds
Subjects: BIOMEDICINE AND HEALTHCARE > Basic Medical Sciences
Divisions: Division of Materials Chemistry
Project titleProject leaderProject codeProject type
Mehanizam bioloških učinaka novih malih molekula na stanice tumora čovjekaLjubica Glavaš Obrovac219-0982914-2176MZOS
Depositing User: Maro Bujak
Date Deposited: 14 Jul 2016 14:17
DOI: 10.2478/10004-1254-64-2013-2371

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