An axial chirality and disorder of positional isomers in a crystal of highly cytotoxic 3-acetyl-1, 3-bis(2-chloro-4-nitrophenyl)-1E-triazene

Molčanov, Krešimir; Polanc, Slovenko; Osmak, Maja; Kojić-Prodić, Biserka (2015) An axial chirality and disorder of positional isomers in a crystal of highly cytotoxic 3-acetyl-1, 3-bis(2-chloro-4-nitrophenyl)-1E-triazene. Acta Chimica Slovenica, 62 (2). pp. 371-377. ISSN 1318-0207

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Abstract

Biologically active 4-nitro-substituted 1, 3-diaryltriazene, a chemical analogue of 1, 3-bis(4'-amidinophenyl)-triazene-berenil®, belongs to the novel, chemically modified class of potent antitumor agents. Its structural characterization by X-ray analysis and 1H NMR spectroscopy is performed to determine molecular overall conformation in view of its possible interaction to DNA.

Item Type:

Article

Uncontrolled Keywords:

axial chirality; enantiomeric disorder; molecular structure; crystal structure

Subjects:

NATURAL SCIENCES > Chemistry

Divisions:

Division of Physical Chemistry

Projects:

Project title	Project leader	Project code	Project type
Cell response to cytotoxic agents and resistance development (Stanični odgovor na citotoksične spojeve i razvoj otpornosti)-	Maja Osmak	098-0982913-2748	MZOS
Protein-ligand interactions at atomic level (Protein-ligand međudjelovanja na atomnoj razini)-	Marija Luić	098-1191344-2943	MZOS

Depositing User:

Krešimir Molčanov

Date Deposited:

06 Jul 2016 14:04

URI:

http://fulir.irb.hr/id/eprint/2899

DOI:

10.17344/acsi.2015.14