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Even stressed cells are individuals: second messengers of free radicals in pathophysiology of cancer

Jaganjac, Morana; Čačev, Tamara; Čipak, Ana; Kapitanović, Sanja; Gall-Troselj, Koraljka; Žarković, Neven (2012) Even stressed cells are individuals: second messengers of free radicals in pathophysiology of cancer. Croatian medical journal, 53 (4). pp. 304-309. ISSN 0353-9504

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Pathophysiological processes associated with disturbances in cell and tissue oxidative homeostasis, are associated with self-catalyzed process of lipid peroxidation. The end products of lipid peroxidation are reactive aldehydes such as 4-hydroxy-2-nonenal (HNE), acting as "second messengers of free radicals." Although reactive aldehydes were first recognized only as cytotoxic, new evidence has come to light, related to their cell growth regulatory functions achieved through cell signaling. The variable appearance of HNE in several organs indicates that its mode of action might be related to an individual cell stress adaptation. The underlying mechanism could be that specific mutations and epigenetic changes on one hand interfere with hormesis on the other. The precise role of oxidative stress and lipid peroxidation in these processes still needs more clarification at molecular level. Finally, an individual approach to each patient, based on the individual cell response to stress, opens a new possibility of integrative medicine in cancer treatment and strongly supports modern concepts of personalized medicine.

Item Type: Article
Uncontrolled Keywords: oxidative stress, personalized medicine
Subjects: BIOMEDICINE AND HEALTHCARE > Basic Medical Sciences
Divisions: Division of Molecular Medicine
Project titleProject leaderProject codeProject type
Epigenetic and immunomodulatery changes in malignant head and neck tumors (Epigenetičke i imunomodulatorne promjene u zloćudnim tumorima glave i vrata)-Koraljka Gall-Trošelj098-0982464-2511MZOS
Molecular genetics and pharmacogenetics of gastrointestinal tumors (Molekularna genetika i farmakogenetika gastrointestinalnih tumora)-Sanja Kapitanović098-0982464-2508MZOS
Lipids, free radicals and their messengers in integrative oncology (Lipidi, slobodni radikali i njihovi glasnici u integrativnoj onkologiji)-Neven Žarković098-0982464-2519MZOS
Depositing User: Sofija Konjević
Date Deposited: 08 Apr 2016 11:39
DOI: 10.3325/cmj.2012.53.304

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