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Response To Hyperoxia Is Associated With Similar Ho-1 Gene Expression Level In Lungs Of Aging Cba Mice Of Both Sexes

Sobočanec, Sandra; Mačak Šafranko, Željka; Šarić, Ana; Korolija, Marina; Popović Hadžija, Marijana; Balog, Tihomir (2016) Response To Hyperoxia Is Associated With Similar Ho-1 Gene Expression Level In Lungs Of Aging Cba Mice Of Both Sexes. Biochemistry and Biophysics Reports, 5 . pp. 55-62. ISSN 2405-5808

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Beside classical antioxidative enzymes, the response to hyperoxia might be mediated via regulation of other systems, such as heme oxygenase (HO). Ho-1 gene expression is found to be upregulated by hyperoxia in all groups of mice, while HO-1 protein isoform was increased only in 4 months old male mice. In steady-state conditions ho-1 and ho-2 gene expression remained unchanged irrespective of sex or age, which was not the case with protein level of both isoforms. This study suggests that in lungs of CBA mice the response to oxidative stress may be mediated through the interaction of other systems such as heme oxygenase, primarily via upregulation of ho-1 gene expression in both sexes. Contrary to our previous study in liver of hyperoxia treated mice, current results might imply that at conventional oxygen conditions lungs of female mice with the emphasis on aging females, are better prepared for oxidative stress conditions through the increase of HO-activity.

Item Type: Article
Uncontrolled Keywords: Heme oxygenase, Antioxidant enzyme, Mouse, Sex-related, Oxygen
Subjects: BIOMEDICINE AND HEALTHCARE > Basic Medical Sciences
Divisions: Division of Molecular Medicine
Project titleProject leaderProject codeProject type
Cytochrome P450 monooxigenas and tumor appearance in ageing and oxidative stress (Sustav citokroma P450 i pojava tumora u starenju i oksidacijskom stresu)-Tihomir Balog098-0982464-1647MZOS
Depositing User: Sofija Konjević
Date Deposited: 19 Jan 2016 16:00
DOI: 10.1016/j.bbrep.2015.09.002

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