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Bidirectional links between Alzheimer's disease and Niemann-Pick type C disease

Malnar, Martina; Hećimović, Silva; Mattsson, Niklas; Zetterberg, Henrik (2014) Bidirectional links between Alzheimer's disease and Niemann-Pick type C disease. Neurobiology of disease, 72 . pp. 37-47. ISSN 0969-9961

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Abstract

Alzheimer's disease (AD) and Niemann-Pick type C (NPC) disease are progressive neurodegenerative diseases with very different epidemiology and etiology. AD is a common cause of dementia with a complex polyfactorial etiology, including both genetic and environmental risk factors, while NPC is a very rare autosomal recessive disease. However, the diseases share some disease-related molecular pathways, including abnormal cholesterol metabolism, and involvement of amyloid-β (Aβ) and tau pathology. Here we review recent studies on these pathological traits, focusing on studies of Aβ and tau pathology in NPC, and the importance of the NPC1 gene in AD. Further studies of similarities and differences between AD and NPC may be useful to increase the understanding of both these devastating neurological diseases.

Item Type: Article
Uncontrolled Keywords: Alzheimer's disease; Amyloid-β; Niemann–Pick type C disease; NPC1; Tau; Cholesterol; Lipids
Subjects: BIOMEDICINE AND HEALTHCARE > Basic Medical Sciences
BIOMEDICINE AND HEALTHCARE > Basic Medical Sciences > Neuroscience
Divisions: Division of Molecular Medicine
Depositing User: Martina Malnar
Date Deposited: 03 Dec 2015 10:48
Last Modified: 01 Jan 2016 00:15
URI: http://fulir.irb.hr/id/eprint/2385
DOI: 10.1016/j.nbd.2014.05.033

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