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The association between catechol-O-methyl-transferase Val108/158Met polymorphism and suicide

Pivac, Nela; Pregelj, Peter; Nikolac, Matea; Zupanc, Tomož; Nedić, Gordana; Muck-Šeler, Dorotea; Videtič Paska, Alja (2011) The association between catechol-O-methyl-transferase Val108/158Met polymorphism and suicide. Genes, Brain and Behavior, 10 (5). pp. 565-569. ISSN 1601-1848

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One of the candidate genes for suicide is also a gene in the pathway for catecholamine degradation encoding an enzyme catehol-O-methyl-transferase (COMT). It harbors a common functional polymorphism, a G to A nucleotide transition resulting in amino acid substitution from valine (Val) to methionine (Met) at position 158 (COMT Val108/158Met ; rs4680) that has been associated with psychiatric disorders characterized with an increased risk of suicidal behavior. We have performed the first study on Caucasian population examining the association between completed suicide and the COMT Val108/158Met polymorphism. The study population consisted of 356 suicide victims and 198 control subjects. Significant difference in COMT Val108/158Met variants (genotypes, alleles and Val carriers) distribution was found only in male groups, between controls and suicide victims (p = 0.018 ; p = 0.031 ; p = 0.005), and between controls and violent suicide victims (p = 0.026 ; p = 0.042 ; p = 0.010). The R value from the standardized residuals revealed that the Met/Met genotype (R = 2.03) in the control group contributed to these significant differences. In contrast to male subjects, no significant differences in the frequency of the COMT Val108/158Met variants were detected between female control and female suicide groups ; however the POC (range 0.161-0.680) was below the desired 0.800. In addition, the logistic regression analysis confirmed these significant differences. In conclusion, our results showed the over-presentation of the Met/Met genotype in male control subjects compared to male suicide victims, suggesting that this genotype of the COMT Val108/158Met might be a protective factor against suicide.

Item Type: Article
Uncontrolled Keywords: catehol-O-methyl-transferase polymorphism; completed suicide; male and female suicide victims
Subjects: BIOMEDICINE AND HEALTHCARE > Clinical Medical Sciences
Divisions: Division of Molecular Medicine
Project titleProject leaderProject codeProject type
Pharmacogenomics and proteomics of serotonergic and catecholaminergic system (Farmakogenomika i proteomika serotoninskog i kateholaminskog sustava)-Dorotea Muck-Šeler098-0982522-2457MZOS
Molecular basis and treatment of psychiatric and stress related disorders (Molekularna podloga i liječenje psihijatrijskih i stresom izazvanih poremećaja)-Nela Pivac098-0982522-2455MZOS
Depositing User: Matea Nikolac Perković
Date Deposited: 04 Dec 2015 09:15
DOI: 10.1111/j.1601-183X.2011.00695.x

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