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Suicide attempts, comorbid depression and platelet serotonin in alcohol dependence

Nenadić-Šviglin, Korona; Nedić, Gordana; Nikolac, Matea; Kozarić-Kovačić, Dragica; Stipčević, Tamara; Muck-Šeler, Dorotea; Pivac, Nela (2011) Suicide attempts, comorbid depression and platelet serotonin in alcohol dependence. Alcohol (Fayetteville, N. Y.), 45 (3). pp. 209-216. ISSN 0741-8329

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The risk of suicide in patients with alcoholism increases if alcoholism is related to comorbid depression. Both alcoholism and suicidal behaviour are associated with reduced serotonin (5-HT) function. Since suicide is enormous public health problem worldwide, to prevent suicidal attempts, it is important to find peripheral marker of suicidal behaviour. The aim of this study was to assess whether altered platelet 5-HT concentration is associated with suicide attempts in alcoholism. Platelet 5-HT concentration was evaluated in 327 male and 87 female ethnically homogenous medication-free patients with alcoholism, subdivided according to the presence or absence of comorbid depression, and/or suicidal behaviour, and in 425 male and 156 female healthy control (non-suicidal) subjects. Suicide attempts were assessed according to the score 4 on the item 3 from the Hamilton Rating Scale for Depression, and according to the structured psychiatric interview about suicidal attempts during lifetime. Patients with alcoholism had significantly lower platelet 5-HT concentration than healthy subjects, and healthy women and female patients with alcoholism had significantly lower platelet 5-HT concentration than the corresponding male subjects. Multifactor analyses of variance revealed the significant effects of sex, alcoholism, comorbid depression, but the lack of significant effects of suicide attempts, and no interactions between variables, on platelet 5-HT concentration. Platelet 5-HT concentration did not differ significantly between suicidal compared to non-suicidal patients with alcoholism. Our results did not confirm the association between platelet 5-HT concentration and suicide attempts in patients with alcoholism.

Item Type: Article
Uncontrolled Keywords: alcoholism; comorbid depression; male and female subjects; platelet serotonin concentration; suicide attempts
Subjects: BIOMEDICINE AND HEALTHCARE > Basic Medical Sciences
Divisions: Division of Molecular Medicine
Project titleProject leaderProject codeProject type
Psychophysiology in the diagnosis of stress-induced disorders (Psihofiziološka dijagnostika poremećaja uzrokovanih stresom)-Dragica Kozarić-Kovačić198-0982522-0075MZOS
Pharmacogenomics and proteomics of serotonergic and catecholaminergic system (Farmakogenomika i proteomika serotoninskog i kateholaminskog sustava)-Dorotea Muck-Šeler098-0982522-2457MZOS
Molecular basis and treatment of psychiatric and stress related disorders (Molekularna podloga i liječenje psihijatrijskih i stresom izazvanih poremećaja)-Nela Pivac098-0982522-2455MZOS
Depositing User: Matea Nikolac Perković
Date Deposited: 03 Dec 2015 14:33
DOI: 10.1016/j.alcohol.2010.11.004

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