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The association between galactosylation of immunoglobulin G and body mass index

Nikolac Perković, Matea; Pučić Baković, Maja; Krištić, Jasminka; Novokmet, Mislav; Huffman, Jennifer E.; Vitart, Veronique; Hayward, Caroline; Rudan, Igor; Wilson, James F.; Campbell, Harry; Polašek, Ozren; Lauc, Gordan; Pivac, Nela (2013) The association between galactosylation of immunoglobulin G and body mass index. Progress in neuro-psychopharmacology and biological psychiatry, 48 . pp. 20-25. ISSN 0278-5846

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Abstract

Obesity is becoming a fast-growing health problem worldwide. Glycosylation of proteins and their variations significantly affect protein structure and function, thus altering numerous physiological and pathophysiological cellular processes. Since plasma glycans were significantly associated with body mass index (BMI) in both Croatian and Chinese populations, the study evaluated the association between immunoglobulin G (IgG) glycome, which is closer to biological function, and BMI. The study included individuals from two Croatian Adriatic islands, Vis and Korčula, and individuals from Northern Scottish Orkney Islands. A hydrophilic interaction chromatography on Waters BEH Glycan chromatography column was used to analyze N-glycans attached to IgG in plasma samples from a total of 3515 individuals. A small but significant positive correlation between BMI and the level of neutral glycans without galactoses was detected. After taking into account the influence of age and gender, correlation coefficients indicated that BMI was responsible for up to 2.0% of variation in the level of neutral glycans without galactoses. Furthermore, after adjusting the effects of age and gender, the level of neutral glycans with two terminal galactoses was negatively associated with BMI in analyzed sample groups, suggesting that BMI could be responsible for up to 3.2% of variation in this glycan feature. Our study is the first large-scale study to indicate the association of BMI and changes in IgG galactosylation. The observed loss of galactose which is associated with increased BMI might be related to chronic inflammation that accompanies the development of obesity.

Item Type: Article
Uncontrolled Keywords: body mass index ; galactosylation ; glycome ; immunoglobulin G
Subjects: BIOMEDICINE AND HEALTHCARE > Basic Medical Sciences
Divisions: Division of Molecular Medicine
Projects:
Project titleProject leaderProject codeProject type
Molecular basis and treatment of psychiatric and stress related disorders (Molekularna podloga i liječenje psihijatrijskih i stresom izazvanih poremećaja)-Nela Pivac098-0982522-2455MZOS
UNSPECIFIEDUNSPECIFIED309-0061194-2022MZOS
Determinants of health and disease in general and isolated human populations (Odrednice zdravlja i bolesti u općoj i izoliranim ljudskim populacijama)-Ozren Polašek216-1080315-0302MZOS
UNSPECIFIEDUNSPECIFIED108-1080315-0302MZOS
Depositing User: Matea Nikolac Perković
Date Deposited: 02 Dec 2015 15:55
Last Modified: 02 Dec 2015 15:55
URI: http://fulir.irb.hr/id/eprint/2360
DOI: 10.1016/j.pnpbp.2013.08.014

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