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Epigenetic regulation of the Hedgehog-Gli signaling pathway in cancer

Car, Diana; Sabol, Maja; Musani, Vesna; Ozretić, Petar; Levanat, Sonja (2010) Epigenetic regulation of the Hedgehog-Gli signaling pathway in cancer. Periodicum Biologorum, 112 (4). pp. 419-423. ISSN 0031-5362

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Abstract

The term epigenetics refers to the modulation of gene expression caused by means other than changes in the DNA sequence. Alongside with genetic alterations, epigenetic changes can also be considered a hallmark of cancer. Epigenetic silencing of tumor suppressors can serve as one of the hits in the Knudson’s two hit model of tumor initiation when in conjunction with genetic mutations or deletions. Also, loss of methylation can be implicated in tumorigenesis by activating normally silent regions of the genome. The Hedgehog-Gli signaling pathway has been highly conserved through evolution and plays a crucial role during embryonic development from Drosophila to humans. Malfunction of the Hh-Gli signaling pathway in humans has first been observed in Gorlin syndrome, characterized by developmental malformations and cancer susceptibility. In the last decades aberrant activation of the Hh-Gli signaling pathway has been implicated in various sporadic tumors, both benign and malignant ones. Genetic alterations of the Hh-Gli signaling pathway components and their implication in the development of various types of cancer and developmental malformations are well known. In the last few years it has become obvious that epigenetic changes also play a crucial role in the regulation of this pathway.

Item Type: Article
Uncontrolled Keywords: Hedgehog signaling; epigenetics; DNA methylation
Subjects: BIOMEDICINE AND HEALTHCARE > Basic Medical Sciences
Divisions: Division of Molecular Medicine
Projects:
Project titleProject leaderProject codeProject type
Signal transduction in tumors: Hh-Gli interactions and therapeutic potential (Prijenos signala u tumorima: Hh-Gli put, interakcije i potencijalne terapije)Sonja Levanat098-0982464-2461MZOS
Depositing User: Maja Sabol
Date Deposited: 20 Nov 2015 14:54
Last Modified: 20 Nov 2015 14:58
URI: http://fulir.irb.hr/id/eprint/2324

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