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The transforming properties of human papillomavirus oncoproteins

Grce, Magdalena; Sabol, Ivan; Milutin Gašperov, Nina (2012) The transforming properties of human papillomavirus oncoproteins. Periodicum Biologorum, 114 (4). pp. 479-487. ISSN 0031-5362

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Human papillomaviruses (HPV) are very common viruses, often causing benign epithelial lesions but, rarely, also cancer. Only long persistent infection with some carcinogenic or high risk HPV types will progress to high-grade lesions and finally cancer. The oncogenic potential of these HR HPV types relies on the role of their major oncoproteins E6 and E7, which bind, inactivate and degrade the two major cellular tumor-suppressor gene products, p53 and the retinoblastoma tumor-suppressor protein (pRb), respectively. The continuous expression of these early oncoproteins can lead to the transformation and immortalization of infected cells. Both, E6 and E7 co-operate to induce transformation of epithelial cells by interacting with numerous host cell proteins affectingmany essential cellular pathways. Herein, the current knowledge on HPV E6 and E7, as well as on the auxiliary E5 oncoprotein is summarized.

Item Type: Article
Uncontrolled Keywords: human papillomavirus; HPV; oncogene; oncoprotein
Subjects: BIOMEDICINE AND HEALTHCARE > Basic Medical Sciences
Divisions: Division of Molecular Medicine
Project titleProject leaderProject codeProject type
Aberrant DNA methylation in HPV associated lesions (Promijenjeno stanje DNA-metilacije u HPV-povezanim oštećenjima)Magdalena Grce098-0982464-2510MZOS
Depositing User: Nina Milutin Gašperov
Date Deposited: 20 Nov 2015 15:02

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