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Hh-Gli signaling pathway activity in oral and oropharyngeal squamous cell carcinoma

Leović, Dinko; Sabol, Maja; Ozretić, Petar; Musani, Vesna; Car, Diana; Marjanović, Ksenija; Zubčić, Vedran; Sabol, Ivan; Sikora, Miroslav; Grce, Magdalena; Glavaš-Obrovac, Ljubica; Levanat, Sonja (2012) Hh-Gli signaling pathway activity in oral and oropharyngeal squamous cell carcinoma. Head and Neck, 34 (1). pp. 104-112. ISSN 1043-3074

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Abstract

The aim of this study was to examine the role of Hh-Gli signaling in oral and oropharyngeal squamous cell carcinoma (SCC). The role of this signaling pathway in SCC formation has not yet been elucidated. Sixty-four tissue and blood samples were collected from 60 SCC patients, all tobacco and alcohol users. Additional 6 buccal mucosa tissue samples were collected from non-smokers and non-drinkers as control tissue. Hedgehog-Gli pathway components were associated with clinical and pathological features. Broders' grade and N stage were associated with higher Ptch1 and lower Gli1 expression. Tumor stage was negatively associated with Smo expression, and tumor size was positively associated with p16 expression. Ptch1 and Shh were frequently detected in the surrounding stroma. Ptch1 was found to be correlated with p16 expression, as well as with survivin expression. The signaling pathway is activated in SCC and inducible in vitro by Shh protein.

Item Type: Article
Uncontrolled Keywords: Hedgehog-Gli signaling; oral cancer; survivin; squamous cell carcinoma
Subjects: BIOMEDICINE AND HEALTHCARE > Basic Medical Sciences
BIOMEDICINE AND HEALTHCARE > Clinical Medical Sciences
BIOMEDICINE AND HEALTHCARE > Clinical Medical Sciences > Otorhinolaryngology
Divisions: Division of Molecular Medicine
Projects:
Project titleProject leaderProject codeProject type
National model of a hospital database for maxillofacial oncology (Nacionalni model kliničke baze podataka u maksilofacijalnoj onkologiji)Mihajlo Virag108-1080057-0043MZOS
Mechanism of biological action of novel small molecules targeting tumor cells (Mehanizam bioloških učinaka novih malih molekula na stanice tumora čovjeka)Ljubica Glavaš Obrovac219-0982914-2176MZOS
Signal transduction in tumors: Hh-Gli interactions and therapeutic potential (Prijenos signala u tumorima: Hh-Gli put, interakcije i potencijalne terapije)Sonja Levanat098-0982464-2461MZOS
Aberrant DNA methylation in HPV associated lesions (Promijenjeno stanje DNA-metilacije u HPV-povezanim oštećenjima)Magdalena Grce098-0982464-2510MZOS
Depositing User: Magdalena Grce
Date Deposited: 20 Nov 2015 14:31
Last Modified: 20 Nov 2015 15:00
URI: http://fulir.irb.hr/id/eprint/2263
DOI: 10.1002/hed.21696

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