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Human papillomavirus status in extragenital nonmelanoma skin cancers

Ledić Drvar, Daniela; Lipozenčić, Jasna; Sabol, Ivan; Bukvić Mokos, Zrinka; Ilić, Ivana; Grce, Magdalena (2014) Human papillomavirus status in extragenital nonmelanoma skin cancers. Clinics in Dermatology, 32 (2). pp. 248-252. ISSN 0738-081X

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About 5% of all cancers worldwide can be attributed to human papillomaviruses (HPVs) ; namely, six sites are strongly associated with HPV infections: cervix, penis, vulva, vagina, anus, and oropharynx. Nonmelanoma skin cancers (NMSC), basal cell carcinoma (BCC), and squamous cell carcinoma (SCC) are the most common malignancies in Caucasians. In fact, there is an intense connection between sunlight exposure, fair skin, HPV, and development of NMSC. We have conducted a pilot study that included tissue samples from 26 carcinoma patients, of which there were 13 BCC and 13 SCC. HPV detection and typing was done with DNA amplification and sequencing, respectively. In total, 23.1% of SCC samples (3/13) and 7.7% of BCC samples (1/13) were positive for HPV DNA. The importance of understanding all aspects of NMSC carcinogenesis may be to reveal novel therapeutic options or preventive measures for HPV containing NMSC patients.

Item Type: Article
Uncontrolled Keywords: Human papillomavirus; basal cell carcinoma; squamous cell carcinoma
Subjects: BIOMEDICINE AND HEALTHCARE > Basic Medical Sciences
BIOMEDICINE AND HEALTHCARE > Clinical Medical Sciences
BIOMEDICINE AND HEALTHCARE > Clinical Medical Sciences > Dermatovenerology
Divisions: Division of Molecular Medicine
Project titleProject leaderProject codeProject type
Aberrant DNA methylation in HPV associated lesions (Promijenjeno stanje DNA-metilacije u HPV-povezanim oštećenjima)-Magdalena Grce098-0982464-2510MZOS
Malignant Epidermal Skin Tumors in Croatia (Maligni epidermalni kožni tumori u Hrvatskoj)-Jasna Lipozenčić218-0000000-3657MZOS
Depositing User: Magdalena Grce
Date Deposited: 13 Nov 2015 14:55
DOI: 10.1016/j.clindermatol.2013.08.009

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