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Geographical Distribution and Risk Association of Human Papillomavirus Genotype 52–Variant Lineages

Zhang, Chuqing; Park, Jong-Sup; Grce, Magdalena; Hibbitts, Samantha; Palefsky, Joel M; Konno, Ryo; Smith-McCune, Karen K; Giovannelli, Lucia; Chu, Tang-Yuan; Picconi, María Alejandra; Piña-Sánchez, Patricia; Settheetham-Ishida, Wannapa; Coutlée, Francois; De Marco, Federico; Woo, Yin-Ling; Ho, Wendy C. S; Wong, Martin C. S; Chirenje, Mike Z; Magure, Tsitsi; Moscicki, Anna-Barbara; Sabol, Ivan; Fiander, Alison N; Chen, Zigui; Chan, Martin C. W; Cheung, Tak-Hong; Burk, Robert D; Chan, Paul K. S. (2014) Geographical Distribution and Risk Association of Human Papillomavirus Genotype 52–Variant Lineages. The Journal of infectious diseases, 210 (10). pp. 1600-1604. ISSN 0022-1899

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Human papillomavirus (HPV) genotype 52 is commonly found in Asian cases of cervical cancer but is rare elsewhere. Analysis of 611 isolates collected worldwide revealed a remarkable geographical distribution, with lineage B predominating in Asia (89.0% vs 0%–5.5% ; Pcorrected < .001), whereas lineage A predominated in Africa, the Americas, and Europe. We propose that the name “Asian lineage” be used to denote lineage B, to signify this feature. Preliminary analysis suggested a higher disease risk for lineage B, although ethnogeographical confounders could not be excluded. Further studies are warranted to verify whether the reported high attribution of disease to HPV52 in Asia is due to the high prevalence of lineage B.

Item Type: Article
Additional Information: This is a pre-copy-editing, author-produced PDF of an article accepted for publication in The Journal of infectious diseases following peer review. The definitive publisher-authenticated version J Infect Dis. (2014) 210 (10): 1600-1604 is available online at:
Uncontrolled Keywords: HPV; cervical cancer; phylogeny; oncogenic risk; Asia
Subjects: BIOMEDICINE AND HEALTHCARE > Basic Medical Sciences
Divisions: Division of Molecular Medicine
Project titleProject leaderProject codeProject type
Aberrant DNA methylation in HPV associated lesions (Promijenjeno stanje DNA-metilacije u HPV-povezanim oštećenjima)-Magdalena Grce098-0982464-2510MZOS
Depositing User: Ivan Sabol
Date Deposited: 13 Nov 2015 16:45
DOI: 10.1093/infdis/jiu310

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