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Kinesin-8 Motors Improve Nuclear Centering by Promoting Microtubule Catastrophe

Glunčić, Matko; Maghelli, Nicola; Krull, Alexander; Krstić, Vladimir; Ramunno-Johnson, Damien; Pavin, Nenad; Tolić, Iva M. (2015) Kinesin-8 Motors Improve Nuclear Centering by Promoting Microtubule Catastrophe. Physical Review Letters, 114 (7). 078103/1-078103/5. ISSN 0031-9007

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In fission yeast, microtubules push against the cell edge, thereby positioning the nucleus in the cell center. Kinesin-8 motors regulate microtubule catastrophe; however, their role in nuclear positioning is not known. Here we develop a physical model that describes how kinesin-8 motors affect nuclear centering by promoting a microtubule catastrophe. Our model predicts the improved centering of the nucleus in the presence of motors, which we confirmed experimentally in living cells. The model also predicts a characteristic time for the recentering of a displaced nucleus, which is supported by our experiments where we displaced the nucleus using optical tweezers.

Item Type: Article
Uncontrolled Keywords: Kinesin-8; Nuclear centering; Microtubule catastrophe
Subjects: NATURAL SCIENCES > Physics > Biophysics and Medical Physics
NATURAL SCIENCES > Biology > Biochemistry and Molecular Biology
Divisions: Division of Molecular Biology
Depositing User: Patrik Risteski
Date Deposited: 22 Oct 2015 11:20
DOI: 10.1103/PhysRevLett.114.078103

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