The influence of body position on cerebrospinal fluid pressure gradient and movement in cats with normal and impaired craniospinal communication

Klarica, Marijan; Radoš, Milan; Erceg, Gorislav; Petošić, Antonio; Jurjević, Ivana; Orešković, Darko (2014) The influence of body position on cerebrospinal fluid pressure gradient and movement in cats with normal and impaired craniospinal communication. PLoS ONE, 9 (4). e95229/1-e95229/11. ISSN 1932-6203

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Abstract

Intracranial hypertension is a severe therapeutic problem, as there is insufficient knowledge about the physiology of cerebrospinal fluid (CSF) pressure. In this paper a new CSF pressure regulation hypothesis is proposed. According to this hypothesis, the CSF pressure depends on the laws of fluid mechanics and on the anatomical characteristics inside the cranial and spinal space, and not, as is today generally believed, on CSF secretion, circulation and absorption. The volume and pressure changes in the newly developed CSF model, which by its anatomical dimensions and basic biophysical features imitates the craniospinal system in cats, are compared to those obtained on cats with and without the blockade of craniospinal communication in different body positions. During verticalization, a long-lasting occurrence of negative CSF pressure inside the cranium in animals with normal cranio-spinal communication was observed. CSF pressure gradients change depending on the body position, but those gradients do not enable unidirectional CSF circulation from the hypothetical site of secretion to the site of absorption in any of them. Thus, our results indicate the existence of new physiological/pathophysiological correlations between intracranial fluids, which opens up the possibility of new therapeutic approaches to intracranial hypertension.

Item Type:	Article
Uncontrolled Keywords:	body position; cerebral perfusion pressure; cerebrospinal fluid; cerebrospinal fluid circulation; cerebrospinal fluid hydrodynamics; cerebrospinal fluid pressure; evolutionary cerebrospinal fluid physiology; hydrostatic pressure gradient; intracranial pressure
Subjects:	BIOMEDICINE AND HEALTHCARE > Basic Medical Sciences
Divisions:	Division of Molecular Biology
Projects:	Project title Project leader Project code Project type Patofiziologija cerebrospinalnog likvora i intrakranijskog tlaka [161760] Marijan Klarica 108-1080231-0023 MZOS Hidrodinamika cerebrospinalnog fluida [81915] Darko Orešković 098-1080231-2328 MZOS
Depositing User:	Iva Tolić
Date Deposited:	10 Jul 2015 07:56
URI:	http://fulir.irb.hr/id/eprint/2049
DOI:	10.1371/journal.pone.0095229

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