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Cationic side-chains control DNA/RNA binding properties and antiproliferative activity of dicationic dibenzotetraaza[14]annulene derivatives

Radić Stojković, Marijana; Marjanović, Marko; Pawlica, Dariusz; Dudek, Lukasz; Eilmes, Julita; Kralj, Marijeta; Piantanida, Ivo (2010) Cationic side-chains control DNA/RNA binding properties and antiproliferative activity of dicationic dibenzotetraaza[14]annulene derivatives. New journal of chemistry, 34 (3). pp. 500-507. ISSN 1144-0546

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Abstract

Studied dicationic dibenzotetraaza[14]annulene derivatives intercalate into synthetic double stranded DNA and RNA, while their positively charged side-chains additionally interact within the minor groove of polynucleotides, contributing to the overall affinity of compounds and controlling pronounced A-T(U) over G-C sequence preference as well as stronger thermal stabilization of ds-DNA than ds-RNA. Furthermore, all compounds showed moderate to high antiproliferative activity against five human tumour cell lines, whereby clear correlation between structure of the side-chain and cytotoxic activity was observed.

Item Type: Article
Uncontrolled Keywords: dibenzotetraaza[14]annulene, DNA and RNA polynucleotides, spectrophotometric titrations, antiproliferative activity, tumour cell lines
Subjects: NATURAL SCIENCES > Mathematics
Divisions: Division of Molecular Medicine
Division of Organic Chemistry and Biochemistry
Projects:
Project titleProject leaderProject codeProject type
Uloga različitih mehanizama odgovora stanica na terapiju oštećenjem DNA-Marijeta Kralj098-0982464-2514MZOS
Dizajn, sinteza i ispitivanje interakcija malih molekula s DNA, RNA i proteinima-Ivo Piantanida098-0982914-2918MZOS
Depositing User: Ivo Piantanida
Date Deposited: 20 Dec 2016 14:27
Last Modified: 20 Dec 2016 14:27
URI: http://fulir.irb.hr/id/eprint/1620
DOI: 10.1039/b9nj00490d

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