hrvatski jezikClear Cookie - decide language by browser settings

Radiation physics and chemistry in heavy-ion cancer therapy

Krajcar Bronić, Ines; Kimura, Mineo (2007) Radiation physics and chemistry in heavy-ion cancer therapy. Kemija u industriji, 56 (12). pp. 643-654. ISSN 0022-9830

[img] PDF
Download (317kB)

Abstract

Heavy ions, such as carbon and oxygen ions, are classified as high-LET radiations, and produce a characteristic dose-depth distribution different from that of low-LET radiations such as gamma ray, x-ray and electrons. Heavy ions loose less energy at the entrance to an irradiated biological system up to some depth than the low-LET radiations, while they dump a large amount of dose within a very narrow range at a certain depth, producing the characteristic sharp peak, and this peak domain of the dose is called the Bragg peak. Therefore, by controlling the Bragg peak, it becomes possible to irradiate only the tumor region in a pin-point manner, while avoiding irradiation of the normal tissue, thus making heavy-ion therapy ideal for deep-seated tumor treatment. However, very little is known about what is going on in terms of physics and chemistry inside the Bragg peak. In this paper the current status of our understanding of heavy-ion interactions and remaining problems of physics and chemistry for the heavy-ion treatment are explored, particularly in the Bragg peak region. Specially, the survey of the basic physical quantity, the mean energy required to form an ion pair (W value) for heavy ions of interest for radiotherapy is presented. Finally, the current clinical status of heavy-ion therapy is presented.

Item Type: Article
Uncontrolled Keywords: heavy ions; radiation therapy; W value; Bragg peak; Oxygen enhancement ratio (OER); Relative biological effectiveness (RBE); Radicals; Ion-bio-molecule interaction; deep-seated tumor
Subjects: NATURAL SCIENCES
NATURAL SCIENCES > Chemistry
Divisions: Division of Experimental Physics
Projects:
Project titleProject leaderProject codeProject type
Prirodni radioizotopi u istraživanju krških ekosustava i datiranju[16101] Nada Horvatinčić098-0982709-2741MZOS
Depositing User: Ines Krajcar Bronić
Date Deposited: 28 Nov 2013 16:06
Last Modified: 21 Apr 2015 10:33
URI: http://fulir.irb.hr/id/eprint/1179

Actions (login required)

View Item View Item

Nema podataka za dohvacanje citata

Downloads

Downloads per month over past year