Overlapping Neuroimmune Mechanisms and Therapeutic Targets in Neurodegenerative Disorders

De Marchi, Fabiola; Munitić, Ivana; Vidatić, Lea; Papić, Eliša; Rački, Valentino; Nimac, Jerneja; Jurak, Igor; Novotni, Gabriela; Rogelj, Boris; Vuletić, Vladimira; Liščić, Rajka; Cannon, Jason R.; Buratti, Emanuele; Mazzini, Letizia; Hećimović, Silva (2023) Overlapping Neuroimmune Mechanisms and Therapeutic Targets in Neurodegenerative Disorders. Biomedicines, 11 (10). ISSN 2227-9059

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Abstract

Many potential immune therapeutic targets are similarly affected in adult-onset neurodegenerative diseases, such as Alzheimer’s (AD) disease, Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), and frontotemporal dementia (FTD), as well as in a seemingly distinct Niemann–Pick type C disease with primarily juvenile onset. This strongly argues for an overlap in pathogenic mechanisms. The commonly researched immune targets include various immune cell subsets, such as microglia, peripheral macrophages, and regulatory T cells (Tregs); the complement system; and other soluble factors. In this review, we compare these neurodegenerative diseases from a clinical point of view and highlight common pathways and mechanisms of protein aggregation, neurodegeneration, and/or neuroinflammation that could potentially lead to shared treatment strategies for overlapping immune dysfunctions in these diseases. These approaches include but are not limited to immunisation, complement cascade blockade, microbiome regulation, inhibition of signal transduction, Treg boosting, and stem cell transplantation.

Item Type:	Article
Uncontrolled Keywords:	Alzheimer’s disease; Parkinson’s disease; Niemann–Pick type C disease; neurodegeneration; neuroinflammation; immunomodulatory therapies; rare diseases
Subjects:	NATURAL SCIENCES > Biology > Biochemistry and Molecular Biology BIOMEDICINE AND HEALTHCARE
Divisions:	Division of Molecular Medicine
Projects:	Project title Project leader Project code Project type Kontrola neurodegeneracije moduliranjem sprege između upale i proteinopatije-ImmunoModifyCNS Ivana Munitić IP-2018-01-8563 HRZZ Generacija i molekularna karakterizacija in vitro i in vivo modela amiotrofične lateralne skleroze- Ivana Munitić uniri-biomed-18-211-1369 NadSve Molekularni mehanizam neurodegeneracije u Niemann-Pickovoj bolesti tip C-neuroNiPiC Silva Katušić Hećimović IP-2016-06-2799 HRZZ
Depositing User:	Ivana Vuglec
Date Deposited:	13 Apr 2026 09:45
URI:	http://fulir.irb.hr/id/eprint/11661
DOI:	10.3390/biomedicines11102793

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