The Associations of Neutrophil–Lymphocyte, Platelet–Lymphocyte, Monocyte–Lymphocyte Ratios and Immune-Inflammation Index with Negative Symptoms in Patients with Schizophrenia

Šagud, Marina; Madžarac, Zoran; Nedić Erjavec, Gordana; Šimunović Filipčić, Ivona; Mikulić, Filip Luka; Rogić, Dunja; Bradaš, Zoran; Bajs Janović, Maja; Pivac, Nela (2023) The Associations of Neutrophil–Lymphocyte, Platelet–Lymphocyte, Monocyte–Lymphocyte Ratios and Immune-Inflammation Index with Negative Symptoms in Patients with Schizophrenia. Biomolecules, 13 (2). ISSN 2218-273X

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Abstract

Neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), monocyte-lymphocyte ratio (MLR) and systemic immune-inflammation index (SII index) are increasingly used as indicators of inflammation in different conditions, including schizophrenia. However, their relationship with negative symptoms, including anhedonia, is largely unknown. Included were 200 patients with schizophrenia and 134 healthy controls (HC), assessed for physical anhedonia (PA), using the Revised Physical Anhedonia Scale (RPAS), and social anhedonia (SA) by the Revised Social Anhedonia Scale (RSAS). Patients were rated by the Positive and Negative Syndrome Scale (PANSS), the Clinical Assessment Interview for Negative Symptoms (CAINS) and the Brief Negative Symptom Scale (BNSS). Most of the negative symptoms were in a weak to moderate positive correlations with blood cell inflammatory ratios, namely, between NLR and MLR with PANSS negative scale, CAINS, and BNSS, and in male patients, between PLR and PANSS negative scale and CAINS. Fewer correlations were detected in females, but also in a positive direction. An exception was SA, given the negative correlation between its severity and the SII index in females, and its presence and higher PLR in males. While different negative symptoms were associated with subclinical inflammation, the relationship between SA and lower inflammatory markers deserves further exploration.

Item Type:	Article
Uncontrolled Keywords:	MLR: monocyte–lymphocyte ratio; NLR: nutrophil–lymphocyte ratio; PLR: platelet–lymphocyte ratio; SCZ: schizophrenia; SII index: systemic immune-inflammation index; negative symptoms of schizophrenia; physical anhedonia; social anhedonia
Subjects:	BIOMEDICINE AND HEALTHCARE
Divisions:	Division of Molecular Medicine
Depositing User:	Kristina Ciglar
Date Deposited:	07 Apr 2026 06:53
URI:	http://fulir.irb.hr/id/eprint/11583
DOI:	10.3390/biom13020297

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