Platelet Serotonin (5-HT) Concentration, Platelet Monoamine Oxidase B (MAO-B) Activity and HTR2A, HTR2C, and MAOB Gene Polymorphisms in Asthma

Konjevod, Marcela; Sreter, Katherina B.; Popovic-Grle, Sanja; Lampalo, Marina; Tudor, Lucija; Jukic, Irena; Nedić Erjavec, Gordana; Bingulac-Popovic, Jasna; Safic Stanic, Hana; Nikolac Perković, Matea; Markeljevic, Jasenka; Samarzija, Miroslav; Pivac, Nela; Švob Štrac, Dubravka (2023) Platelet Serotonin (5-HT) Concentration, Platelet Monoamine Oxidase B (MAO-B) Activity and HTR2A, HTR2C, and MAOB Gene Polymorphisms in Asthma. Biomolecules, 13 (5). ISSN 2218-273X

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Abstract

The complex role of the serotonin system in respiratory function and inflammatory diseases such as asthma is unclear. Our study investigated platelet serotonin (5-HT) levels and platelet monoamine oxidase B (MAO-B) activity, as well as associations with HTR2A (rs6314; rs6313), HTR2C (rs3813929; rs518147), and MAOB (rs1799836; rs6651806) gene polymorphisms in 120 healthy individuals and 120 asthma patients of different severity and phenotypes. Platelet 5-HT concentration was significantly lower, while platelet MAO-B activity was considerably higher in asthma patients; however, they did not differ between patients with different asthma severity or phenotypes. Only the healthy subjects, but not the asthma patients, carrying the MAOB rs1799836 TT genotype had significantly lower platelet MAO-B activity than the C allele carriers. No significant differences in the frequency of the genotypes, alleles, or haplotypes for any of the investigated HTR2A, HTR2C and MAOB gene polymorphisms have been observed between asthma patients and healthy subjects or between patients with various asthma phenotypes. However, the carriers of the HTR2C rs518147 CC genotype or C allele were significantly less frequent in severe asthma patients than in the G allele carriers. Further studies are necessary to elucidate the involvement of the serotonergic system in asthma pathophysiology.

Item Type:	Article
Uncontrolled Keywords:	asthma; platelet MAO-B activity; platelet 5-HT levels; MAOB; 5HT2A; 5HT2C polymorphisms; haplotype analysis; severity; phenotypes
Subjects:	BIOMEDICINE AND HEALTHCARE
Divisions:	Division of Molecular Medicine
Depositing User:	Josipa Karadžole
Date Deposited:	25 Mar 2026 11:58
URI:	http://fulir.irb.hr/id/eprint/11474
DOI:	10.3390/biom13050800

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