Metal‐Free C−X Functionalization in Solid‐State via Photochemistry in Ball Mills

Spula, Carolina; Becker, Valentin; Talajić, Gregor; Grätz, Sven; Užarević, Krunoslav; Borchardt, Lars (2025) Metal‐Free C−X Functionalization in Solid‐State via Photochemistry in Ball Mills. ChemSusChem, 18 (5). ISSN 1864-5631

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Abstract

We report the first metal- and catalyst-free protocol for the facile cross-coupling of aryl halides towards C-B, C-P and C-S bonds under solid-state ball milling conditions via UV light irradiation. The reactions can be performed in the absence of bulk solvents at room temperature in a mixer mill, yielding up to 99 % and being tolerant towards various functionalized aryl halides (X=I or Br). Furthermore, we developed a novel photoreactor design increasing the light intensity. With this, we could demonstrate that our protocol surpasses classical solvent-based as well as purely mechanochemical approaches in terms of green metrics and energy efficiency.

Item Type:	Article
Uncontrolled Keywords:	Photomechanochemistry; UV-light solid-state reactivity; New photoreactors
Subjects:	NATURAL SCIENCES NATURAL SCIENCES > Chemistry NATURAL SCIENCES > Chemistry > Physical Chemistry NATURAL SCIENCES > Chemistry > Organic Chemistry
Divisions:	Division of Physical Chemistry
Projects:	Project title Project leader Project code Project type Važnost mehanokemijske reaktivnosti u prebiotičkoj kemijskoj evoluciji i njezin prijenos na održivu kemijsku proizvodnju s niskim emisijama-PREBIOMECHEM Krunoslav Užarević IP-2020-02-4702 HRZZ
Depositing User:	Krunoslav Užarević
Date Deposited:	28 Jan 2026 11:07
URI:	http://fulir.irb.hr/id/eprint/11166
DOI:	10.1002/cssc.202401022

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