Mass Spectrometry Advances in Analysis of Glioblastoma

Al Shboul, Sofian; Singh, Ashita; Kobetić, Renata; Goodlett, David R.; Brennan, Paul M.; Hupp, Ted; Đapić, Irena (2024) Mass Spectrometry Advances in Analysis of Glioblastoma. Mass Spectrometry Reviews, 2024; 1–35, 44 (4). pp. 630-664. ISSN 0277-7037

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Abstract

Some cancers such as glioblastoma (GBM), show minimal response to medical interventions, often only capable of mitigating tumor growth or alleviating symptoms. High metabolic activity in the tumor microenvironment marked by immune responses and hypoxia, is a crucial factor driving tumor progression. The many developments in mass spectrometry (MS) over the last decades have provided a pivotal tool for studying proteins, along with their posttranslational modifications. It is known that the proteomic landscape of GBM comprises a wide range of proteins involved in cell proliferation, survival, migration, and immune evasion. Combination of MS imaging and microscopy has potential to reveal the spatial and molecular characteristics of pathological tissue sections. Moreover, integration of MS in the surgical process in form of techniques such as DESI‐MS or rapid evaporative ionization MS has been shown as an effective tool for rapid measurement of metabolite profiles, providing detailed information within seconds. In immunotherapy‐related research, MS plays an indispensable role in detection and targeting of cancer antigens which serve as a base for antigen‐specific therapies. In this review, we aim to provide detailed information on molecular profile in GBM and to discuss recent MS advances and their clinical benefits for targeting this aggressive disease.

Item Type:	Article
Additional Information:	"This is the peer reviewed version of the following article: Al Shboul, S., Singh, A., Kobetic, R., Goodlett, D.R., Brennan, P.M., Hupp, T. and Dapic, I. (2025), Mass Spectrometry Advances in Analysis of Glioblastoma. Mass Spectrometry Reviews, 44: 630-664. https://doi.org/10.1002/mas.21912, which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited."
Uncontrolled Keywords:	glioblastoma; glycans; lipids; mass spectrometry; proteomics; tissues
Subjects:	NATURAL SCIENCES > Chemistry > Analytic Chemistry
Divisions:	Division of Organic Chemistry and Biochemistry
Depositing User:	Renata Kobetić
Date Deposited:	14 Jan 2026 14:56
URI:	http://fulir.irb.hr/id/eprint/10839
DOI:	10.1002/mas.21912

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