Life-cycle-coupled evolution of mitosis in close relatives of animals

Shah, Hiral; Olivetta, Marine; Bhickta, Chandni; Ronchi, Paolo; Trupinić, Monika; Tromer, Eelco C.; Tolić, Iva M.; Schwab, Yannick; Dudin, Omaya; Dey, Gautam (2024) Life-cycle-coupled evolution of mitosis in close relatives of animals. Nature, 630 (8015). pp. 116-122. ISSN 0028-0836

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Abstract

Eukaryotes have evolved towards one of two extremes along a spectrum of strategies for remodelling the nuclear envelope during cell division: disassembling the nuclear envelope in an open mitosis or constructing an intranuclear spindle in a closed mitosis. Both classes of mitotic remodelling involve key differences in the core division machinery but the evolutionary reasons for adopting a specific mechanism are unclear. Here we use an integrated comparative genomics and ultrastructural imaging approach to investigate mitotic strategies in Ichthyosporea, close relatives of animals and fungi. We show that species in this clade have diverged towards either a fungal-like closed mitosis or an animal-like open mitosis, probably to support distinct multinucleated or uninucleated states. Our results indicate that multinucleated life cycles favour the evolution of closed mitosis.

Item Type:	Article
Uncontrolled Keywords:	nuclear-envelope; cell-division; dynamics; origin
Subjects:	NATURAL SCIENCES > Biology
Divisions:	Division of Molecular Biology
Projects:	Project title Project leader Project code Project type Molecular origins of aneuploidies in healthy and diseased human tissues-ANEUPLOIDY Iva Tolić; Nenad Pavin 855158 EK Ravnoteža sila i momenta sila u diobenom vretenu-SpindleForceBalance Nenad Pavin IP-2019-04-5967 HRZZ Inovativni protokoli mikroskopije za interdisciplinarna istraživanja u biomedicini-IPSted Iva Tolić KK.01.1.1.04.0057 EK Provedba vrhunskih istraživanja u sklopu Znanstvenog centra izvrsnosti za kvantne i kompleksne sustave te reprezentacije Liejevih algebri-QuantiXLie Hrvoje Buljan; Pavle Pandžić; Vit Tuček; Tomislav Marketin KK.01.1.1.01.0004 EK
Depositing User:	Iva Marija Tolić
Date Deposited:	07 Jan 2026 13:55
URI:	http://fulir.irb.hr/id/eprint/10722
DOI:	10.1038/s41586-024-07430-z

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