Gitlin-Domagalska, Agata; Olejnik, Anna; Ptaszyńska, Natalia; Ruczyński, Jaroslaw; Glavaš, Mladena; Marszałek, Mikolaj; Dębowski, Dawid; Helbik-Maciejewska, Aleksandra; Łęgowska, Anna; Gilon, Chaim; Rolka, Krzysztof (2024) Lipophilic Prodrug Charge Masking- insights into new method of peptide prodrugs synthesis conception. In: Rovero, Paolo; Chorev, Michael; Cavelier, Florine; Li, Xuechen; Matsuzaki, Katsumi; Wade, John, (eds.) EPS 2024: Book of Abstracts. United Kingdom, John Wiley & Sons, pp. 205-206 .
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Abstract
Lipophilic Prodrug Charge Masking (LPCM) strategy was first described in 2018 by Schumacher et al. [1] as an answer to a growing need of peptide drugs oral delivery. In short, LPCM assumes transitional masking of hydrophilic peptides' charge by alkoxycarbonyl groups. These modifications are supposed to be removed by esterases after permeating in the intestine to the bloodstream. Initial studies proved the hypothesis and showed excellent and promising results. This outcome encouraged us to look closer to LPCM as a way to transform peptides into bioavailable drugs. We intended to verify its application to commonly known and applied peptide drugs with proved biological activity.
| Item Type: | Conference or workshop item published in conference proceedings (UNSPECIFIED) | ||||||||
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| Uncontrolled Keywords: | solid phase peptide synthesis; vasopressin; desmopressin | ||||||||
| Subjects: | NATURAL SCIENCES > Chemistry > Organic Chemistry NATURAL SCIENCES > Biology > Biochemistry and Molecular Biology |
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| Divisions: | NMR Center | ||||||||
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| Depositing User: | Mladena Glavaš | ||||||||
| Date Deposited: | 18 Dec 2025 14:41 | ||||||||
| URI: | http://fulir.irb.hr/id/eprint/10589 |
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