Versatile magnetic nanocarriers for water-insoluble and low-stability drugs: Enhanced controlled release by external magnetic fields

Mandić, Lucija; Šegota, Suzana (2025) Versatile magnetic nanocarriers for water-insoluble and low-stability drugs: Enhanced controlled release by external magnetic fields. Journal of Drug Delivery Science and Technology, 116 . pp. 107848-107861. ISSN 1773-2247

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Abstract

Flavonoids possess significant therapeutic potential owing to their anti-inflammatory, anti-cancer, and antioxidant properties, attributed to their polyphenolic structure. However, limited bioavailability and absorption in the body, poor solubility in water and instability in physiological conditions reduce their effectiveness as biologically active substances. In this study, we explored the potential of magnetite nanocarriers functionalized with polyethylene glycol (PEG), strategically developed to address the critical challenges of flavonoid delivery, including their low solubility and instability under physiological conditions. This approach holds promise due to biocompatibility, favorable physicochemical properties, and superparamagnetic behavior of magnetite nanocarriers. Flavonoids, including quercetin, myricetin, and myricitrin were encapsulated into the magnetite nanocarriers using the adsorption method, and their loading efficiency was quantified using UV–Vis spectroscopy. The in vitro kinetics of flavonoid release from magnetite nanocarriers were precisely controlled through the synergistic application of external permanent and oscillating magnetic fields, and quantification via UV–Vis spectroscopy further validated the system's exceptional precision. The results demonstrated the successful development of a highly efficient and versatile nanocarrier capable of simultaneously encapsulating both hydrophobic and hydrophilic flavonoids. Additionally, the study revealed that the controlled release of flavonoids from magnetite nanocarriers can be achieved by controlling the external oscillating and permanent magnetic field, which also opens avenues for advanced, magnetically controlled drug delivery systems, marking a significant advancement in nanotechnology-enabled therapeutics.

Item Type:	Article
Uncontrolled Keywords:	magnetite nanocarrier; flavonoids; drug delivery; drug release; magnetic field; superparamagnetism
Subjects:	NATURAL SCIENCES > Chemistry > Physical Chemistry
Divisions:	Division of Physical Chemistry
Projects:	Project title Project leader Project code Project type Zaštitni mehanizmi i učinci flavonoida ugrađenih u nanonosače u modelnim membranama i neuronima-NanoFlavNeuroProtect Suzana Šegota IP-2016-06-8415 HRZZ
Depositing User:	Suzana Šegota
Date Deposited:	10 Dec 2025 12:51
URI:	http://fulir.irb.hr/id/eprint/10288
DOI:	10.1016/j.jddst.2025.107848

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