Role of TLRs in HIV-1 Infection and Potential of TLR Agonists in HIV-1 Vaccine Development and Treatment Strategies

Rozman, Marija; Zidovec-Lepej, Snjezana; Jambrošić, Karlo; Babić, Maja; Drmić Hofman, Irena (2023) Role of TLRs in HIV-1 Infection and Potential of TLR Agonists in HIV-1 Vaccine Development and Treatment Strategies. Pathogens, 12 . ISSN 2076-0817

PDF - Published Version - article Available under License Creative Commons Attribution. Download (2MB)

Abstract

Toll-like receptors (TLRs), as a family of pattern recognition receptors, play an important role in the recognition of HIV-1 molecular structures by various cells of the innate immune system, but also provide a functional association with subsequent mechanisms of adaptive immunity. TLR7 and TLR8 play a particularly important role in the innate immune response to RNA viruses due to their ability to recognise GU-rich single-stranded RNA molecules and subsequently activate intracellular signalling pathways resulting in expression of genes coding for various biological response modifiers (interferons, proinflammatory cytokines, chemokines). The aim of this review is to summarise the most recent knowledge on the role of TLRs in the innate immune response to HIV-1 and the role of TLR gene polymorphisms in the biology and in the clinical aspects of HIV infections. In addition, the role of TLR agonists as latency reversing agents in research to treat HIV infections and as immunomodulators in HIV vaccine research will be discussed.

Item Type:	Article
Uncontrolled Keywords:	HIV-1; Toll-like receptors (TLRs); innate immunity; TLR agonists; latency reversing agents (LRAs)
Subjects:	BIOMEDICINE AND HEALTHCARE > Clinical Medical Sciences > Infectology
Divisions:	Center for Marine Research
Projects:	Project title Project leader Project code Project type Molekularna epidemiologija, kliničke osobitosti i skrb za osobe zaražene HIV-om u Hrvatskoj-MEKOSH/MECCHC Josip Begovac; Ivana Benković; Šime Zekan; Vanja Romih Pintar; Klaudija Višković; Maja Oroz; Snježana Židovec-Lepej; Lana Gorenec; Ivana Grgić; Oktavija Đaković Rode; Davorka Lukas; Ana Planinić IP-2019-04-9702 HRZZ
Depositing User:	Josipa Karadžole
Date Deposited:	07 Nov 2025 14:49
URI:	http://fulir.irb.hr/id/eprint/10183
DOI:	10.3390/pathogens12010092

Actions (login required)

View Item